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Palladium-Catalyzed Suzuki-Miyaura Couplings of Glycal Boronates with Aryl Thianthrenium Salts for the Synthesis of C-Aryl Glycals

文献类型：期刊论文

作者Zhang, Yu1,2,3; Guan, Chengyang3; Zeng, Mingjie1,4; Wang, Qian3; Liu, Hong1,4,5; Wang, Jiang1,2,3,5
刊名ORGANIC LETTERS
出版日期2025-09-26
卷号27期号:38页码:10778-10784
ISSN号1523-7060
DOI10.1021/acs.orglett.5c03390
英文摘要Aryl C-glycosides represent key structure motifs in numerous natural products and pharmaceuticals. Here, we report a palladium-catalyzed Suzuki-Miyaura cross-coupling reaction between glycal boronates and aryl thianthrenium salts under mild conditions, enabling the synthesis of C-aryl glycals. This method features broad substrate scope, excellent functional group tolerance, and operational simplicity. Furthermore, the synthetic utility of this strategy is demonstrated through late-stage functionalization of structurally complex drug molecules, underscoring its potential for medicinal chemistry applications.
WOS关键词H FUNCTIONALIZATION ; GLYCOSIDES ; ARYLATION ; ALKYL
资助项目National Natural Science Foundation of China[22177124] ; National Natural Science Foundation of China[82322063] ; National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[22337003] ; National Natural Science Foundation of China[92253305] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[23XD1460300] ; Program of Shanghai Academic Research Leader[2022YFA1302900] ; National Key R&D Program of China
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001573356800001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/321507]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Liu, Hong; Wang, Jiang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Pharmaceut Sci, Dept Med Chem, Shanghai 200240, Peoples R China
3.Lingang Lab, Shanghai 200031, Peoples R China
4.China Pharmaceut Univ, Nanjing 211198, Jiangsu, Peoples R China
5.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yu,Guan, Chengyang,Zeng, Mingjie,et al. Palladium-Catalyzed Suzuki-Miyaura Couplings of Glycal Boronates with Aryl Thianthrenium Salts for the Synthesis of C-Aryl Glycals[J]. ORGANIC LETTERS,2025,27(38):10778-10784.
APA Zhang, Yu,Guan, Chengyang,Zeng, Mingjie,Wang, Qian,Liu, Hong,&Wang, Jiang.(2025).Palladium-Catalyzed Suzuki-Miyaura Couplings of Glycal Boronates with Aryl Thianthrenium Salts for the Synthesis of C-Aryl Glycals.ORGANIC LETTERS,27(38),10778-10784.
MLA Zhang, Yu,et al."Palladium-Catalyzed Suzuki-Miyaura Couplings of Glycal Boronates with Aryl Thianthrenium Salts for the Synthesis of C-Aryl Glycals".ORGANIC LETTERS 27.38(2025):10778-10784.

入库方式： OAI收割

来源：上海药物研究所

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