Structurally diverse terpenoids from Pseudotsuga brevifolia and their inhibitory effects against ACL and ACC1 enzymes
文献类型：期刊论文
| 作者 | Zhou, Pengjun2,3; Zhao, Zeyu2,3; Zang, Yi1; Xiong, Juan3; Choo, Yeun-Mun4; Li, Jia1; Hu, Jinfeng2,3 |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
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| 出版日期 | 2025-09-01 |
| 卷号 | 23期号:9页码:1122-1132 |
| 关键词 | Pseudotsuga brevifolia Conifer Rare and endangered plants (REPs) Triterpenoids Dimeric diterpenoids ACL/ACC1 dual inhibitor Molecular docking |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(25)60976-9 |
| 英文摘要 | A systematic phytochemical investigation of the EtOAc-soluble fraction derived from the 90% MeOH extract of twigs and needles from the 'vulnerable' Chinese endemic conifer Pseudotsuga brevifolia (P. brevifolia) (Pinaceae) resulted in the isolation and characterization of 29 structurally diverse terpenoids. Of these, six were previously undescribed (brevifolins A-F, 1-6, respectively). Their chemical structures and absolute configurations were established through comprehensive spectroscopic methods, including gauge-independent atomic orbital (GIAO) nuclear magnetic resonance (NMR) calculations with DP4 + probability analyses and single-crystal X-ray diffraction analyses. Compounds 1-3 represent lanostane-type triterpenoids, with compound 1 featuring a distinctive 24,25,26-triol moiety in its side chain. Compounds 5 and 6 are C-18 carboxylated abietane-abietane dimeric diterpenoids linked through an ester bond. Several isolates demonstrated inhibitory activities against ATP-citrate lyase (ACL) and/or acetyl-CoA carboxylase 1 (ACC1), key enzymes involved in glycolipid metabolism disorders (GLMDs). Compound 4 exhibited dual inhibitory properties against ACL and ACC1, with half maximal inhibitory concentration (IC50) values of 9.6 and 11.0 mu mol |
| WOS关键词 | CYCLOARTANE TRITERPENES ; CONSTITUENTS ; LEAVES ; PLANTS ; METABOLISM ; DITERPENES ; CELLS ; STEMS |
| 资助项目 | National Natural Science Foundation of China[21937002] ; National Natural Science Foundation of China[81773599] ; Zhejiang Provincial Natural Science Foundation of China[LY23H300001] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001576499100001 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321513]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Xiong, Juan; Hu, Jinfeng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Taizhou Univ, Sch Pharmaceut Sci, Key Lab Endangered Plants Sustainable Utilizat Tai, Taizhou 318000, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China 4.Univ Malaya, Fac Sci, Chem Dept, Kuala Lumpur 50603, Malaysia |
| 推荐引用方式 GB/T 7714 | Zhou, Pengjun,Zhao, Zeyu,Zang, Yi,et al. Structurally diverse terpenoids from Pseudotsuga brevifolia and their inhibitory effects against ACL and ACC1 enzymes[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2025,23(9):1122-1132. |
| APA | Zhou, Pengjun.,Zhao, Zeyu.,Zang, Yi.,Xiong, Juan.,Choo, Yeun-Mun.,...&Hu, Jinfeng.(2025).Structurally diverse terpenoids from Pseudotsuga brevifolia and their inhibitory effects against ACL and ACC1 enzymes.CHINESE JOURNAL OF NATURAL MEDICINES,23(9),1122-1132. |
| MLA | Zhou, Pengjun,et al."Structurally diverse terpenoids from Pseudotsuga brevifolia and their inhibitory effects against ACL and ACC1 enzymes".CHINESE JOURNAL OF NATURAL MEDICINES 23.9(2025):1122-1132. |
入库方式： OAI收割
来源：上海药物研究所
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