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Applying natural product repurposing strategy to identify baicalein as novel caseinolytic protease P inhibitor and its application in the treatment of rice bacterial diseases

文献类型：期刊论文

作者Sun, Zhaoju1; Yang, Teng2; Long, Zhouqing1; Fu, Xichun1; Meng, Jiao1; Zhou, Xiang1; Yang, Cai-Guang2,3,4; Yang, Song1
刊名PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
出版日期2025-11-01
卷号214页码:12
关键词Plant bacterial diseases ClpP inhibitor Natural products Baicalein Rice
ISSN号0048-3575
DOI10.1016/j.pestbp.2025.106577
英文摘要Plant diseases caused by bacteria affect the yield of crop, greatly reduce the quality of food, and thus posing a great threat to food safety. To fill the gap that no report about ClpP inhibitor is applied in agri-food production field, engineering natural-product repurposing strategy, 55 of natural products were screened using the combination of ClpP inhibitors of Xanthomonas oryzae pv. oryzae (Xoo) screening assay and anti-Xoo activity experiment. Outcomes showed that naturally occurring baicalein possessed favorable peptidase inhibitory activity against XooClpP (IC50 = 130.32 mu M) and in vitro anti-Xoo activity (EC50 = 7.11 mg L-1). Transcriptome analysis indicated that baicalein directly interacted with XooClpP, reduced the stability of XooClpP, further inhibited intracellular processes including oxidative phosphorylation and tricarboxylic acid cycle, and thus kill bacteria. Overall, this study highlights interesting insights into baicalein as a new inhibitor of XooClpP, and shows its unprecedented prospect as new bactericide candidate for ensuring the crop health and food safety.
WOS关键词ORYZAE-PV.-ORYZAE ; CELL-DIVISION ; CLPP ; DYSREGULATION ; ARREST
资助项目National Natural Science Foundation of China[32372610] ; National Natural Science Foundation of China[U23A20201] ; National Natural Science Foundation of China[32160661] ; National Natural Science Foundation of China[32202359] ; National Key Research and Development Program of China[2022YFD1700300] ; Central Government Guides Local Science and Technology Development Fund Projects[[Qiankehezhongyindi (2023) 001]] ; Central Government Guides Local Science and Technology Development Fund Projects[[Qiankehezhongyindi (2024) 007]]
WOS研究方向Biochemistry & Molecular Biology ; Entomology ; Physiology
语种英语
WOS记录号WOS:001573590500001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/321567]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Zhou, Xiang; Yang, Cai-Guang; Yang, Song
作者单位1.Ctr R&D Fine Chem Guizhou Univ, Minist Educ, State Key Lab Green Pesticides, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China
2.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Chem Biol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Zhaoju,Yang, Teng,Long, Zhouqing,et al. Applying natural product repurposing strategy to identify baicalein as novel caseinolytic protease P inhibitor and its application in the treatment of rice bacterial diseases[J]. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,2025,214:12.
APA Sun, Zhaoju.,Yang, Teng.,Long, Zhouqing.,Fu, Xichun.,Meng, Jiao.,...&Yang, Song.(2025).Applying natural product repurposing strategy to identify baicalein as novel caseinolytic protease P inhibitor and its application in the treatment of rice bacterial diseases.PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,214,12.
MLA Sun, Zhaoju,et al."Applying natural product repurposing strategy to identify baicalein as novel caseinolytic protease P inhibitor and its application in the treatment of rice bacterial diseases".PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 214(2025):12.

入库方式： OAI收割

来源：上海药物研究所

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