Alantolactone: structural enhancements and therapeutic insights for cancer and inflammation
文献类型：期刊论文
| 作者 | Kayumov, Muzaffar3,4,5; Sobirova, Fotima A.1; Khasanov, Okhunjon2; Mukhamedov, Nurkhodja3; Asrorov, Akmal M.3; Mirzaakhmedov, Sharafitdin3 |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2025-10-06 |
| 页码 | 18 |
| 关键词 | Alantolactone anticancer anti-inflammatory structure transformation |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2025.2571848 |
| 英文摘要 | Alantolactone (ATL) is a bioactive sesquiterpene lactone derived from medicinal plants that exhibits numerous biological activities, especially its anti-cancer and anti-inflammatory properties. The review examines the current evidence on ATL's bioactivity and details how ATL functions across various cancer cell lines (breast, lung, gastric, pancreatic, bone and liver cancers) and inflammation processes. The clinical application of ATL faces limitations due to its inadequate solubility in water and non-selectively binding to non-target proteins. Therefore, we summarised existing structural transformation methods, including acid-catalyzed, oxidative, reductive reactions, cycloaddition, rearrangement of lactone ring, Aza-Michael, cross-coupling and click reactions that might further promote to overcome these limitations. This work presents ATL as an effective anticancer natural product and reviews the last decade of anti-tumour and inflammatory activities, with the mechanism of actions and gives the main points of existing structural optimisation techniques which may assist the researchers to improve effectiveness while minimising negative side effects. |
| WOS关键词 | SESQUITERPENE LACTONES ; INULA-HELENIUM ; DERIVATIVES ; EUDESMANOLIDES ; APOPTOSIS ; OSTEOSARCOMA ; PATHWAY ; CELLS |
| 资助项目 | Chinese Government Scholarship Program |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001590777400001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321618]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Kayumov, Muzaffar |
| 作者单位 | 1.Alfrganus Univ, Dept Pharm & Chem, Tashkent, Uzbekistan 2.Kimyo Int Univ, Dept Med Biol Sci, Tashkent, Uzbekistan 3.Uzbek Acad Sci, Inst Bioorgan Chem, Tashkent, Uzbekistan 4.Natl Univ Uzbekistan, Dept Nat Cpds & Appl Chem, Tashkent, Uzbekistan 5.Chinese Acad Sci, Shanghai Inst Mat Med, Canc Res Ctr, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kayumov, Muzaffar,Sobirova, Fotima A.,Khasanov, Okhunjon,et al. Alantolactone: structural enhancements and therapeutic insights for cancer and inflammation[J]. NATURAL PRODUCT RESEARCH,2025:18. |
| APA | Kayumov, Muzaffar,Sobirova, Fotima A.,Khasanov, Okhunjon,Mukhamedov, Nurkhodja,Asrorov, Akmal M.,&Mirzaakhmedov, Sharafitdin.(2025).Alantolactone: structural enhancements and therapeutic insights for cancer and inflammation.NATURAL PRODUCT RESEARCH,18. |
| MLA | Kayumov, Muzaffar,et al."Alantolactone: structural enhancements and therapeutic insights for cancer and inflammation".NATURAL PRODUCT RESEARCH (2025):18. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。