Charge modulation in D-A-D molecules: an acid-responsive NIR-II nanoplatform for imaging and photothermal therapy
文献类型：期刊论文
| 作者 | Gao, Shu1,4; Wang, Jiahui3; Wei, Xiaonan4,5; Wang, Jun1,4; Jiang, Yuanpeng1,4; Tan, Boyu4,6; Qin, Yeshan4; Zhu, Xiaoyang7; Song, Ruihu4; Qu, Chunrong4 |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2025-09-24 |
| 页码 | 10 |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/d5bm01084e |
| 英文摘要 | Small-molecule near-infrared (NIR) dyes have shown great promise in bioimaging and theranostics of diseases. Among them, D-A-D-structured molecules stand out because of their excellent photostability, second near-infrared window (NIR-II, 1000-2000 nm) emission, and large Stokes shifts, offering significant imaging advantages and application potential. However, compared to conventional BODIPY and cyanine-based dyes, D-A-D molecules are generally uncharged and exhibit poor solubility, which limit their further application in biological systems. To date, systematic studies on the photophysical properties of charged D-A-D molecules have remained scarce. Considering the importance of structural modulation, a detailed investigation of their optical properties is of great significance for rational design of practical and high-performance dyes. In this study, two groups of D-A-D-type small-molecule dyes were rationally designed and synthesized based on a donor-acceptor engineering strategy. The influence of charge incorporation on their photophysical properties was systematically evaluated. Among them, SMIC-10004 exhibited excellent optical stability, good polarity, and favorable NIR-II emission characteristics. Based on this, an acid-responsive nanoprobe, SMIC-10004 NPs, was constructed using mPEG-Hyd-DSPE to enhance accumulation in the tumor microenvironment. In vivo experiments demonstrated that SMIC-10004 NPs enabled high-resolution and long-term NIR-II imaging, and the nanoparticles significantly inhibited tumor growth under laser irradiation, showing superior photothermal therapeutic efficacy with good biocompatibility. Overall, this study not only provides valuable guidance for the rational design of charged D-A-D dyes, but also presents a promising platform for NIR-II-based theranostic applications. |
| WOS关键词 | DELIVERY ; DESIGN ; DYES |
| 资助项目 | National Natural Science Foundation of China[U2267221] ; National Natural Science Foundation of China[XDB0830300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[SYS202205] ; Shandong Laboratory Program |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001586986600001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321624]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Qu, Chunrong; Qian, Kun; Cheng, Zhen |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Tianjin Univ Tradit Chinese Med, Tianjin 301617, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Shandong First Med Univ & Shandong Acad Med Sci, 6699 Qingdao Rd, Jinan 250000, Shandong, Peoples R China 6.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 201210, Peoples R China 7.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Shu,Wang, Jiahui,Wei, Xiaonan,et al. Charge modulation in D-A-D molecules: an acid-responsive NIR-II nanoplatform for imaging and photothermal therapy[J]. BIOMATERIALS SCIENCE,2025:10. |
| APA | Gao, Shu.,Wang, Jiahui.,Wei, Xiaonan.,Wang, Jun.,Jiang, Yuanpeng.,...&Cheng, Zhen.(2025).Charge modulation in D-A-D molecules: an acid-responsive NIR-II nanoplatform for imaging and photothermal therapy.BIOMATERIALS SCIENCE,10. |
| MLA | Gao, Shu,et al."Charge modulation in D-A-D molecules: an acid-responsive NIR-II nanoplatform for imaging and photothermal therapy".BIOMATERIALS SCIENCE (2025):10. |
入库方式： OAI收割
来源：上海药物研究所
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