A triple-responsive nanozyme platform of AgAu-CeO2 heterojunction integrated with probiotics for precision antibacterial therapy in periodontitis
文献类型：期刊论文
| 作者 | Li, Meiqi3; Ding, Qihang4; Hu, Songtao5; Qi, Manlin3; Sun, Jiao6; Shi, Yujia3; Dong, Biao5; Qian, Kun1; Sun, Xiaolin3; Cheng, Zhen1,2 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2026-04-01 |
| 卷号 | 327页码:13 |
| 关键词 | Nanozymes Probiotics Antibacterial therapy Cerium dioxide Peroxidase-like activity Reactive oxygen species Periodontitis |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2025.123731 |
| 英文摘要 | Nanozymes hold significant promise for biomedical applications; however, their clinical translation is hindered by the mismatch between physiological conditions and their optimal catalytic environments, particularly with respect to temperature and pH. To address this challenge, we developed a multifunctional composite nanozyme (AgAu C-L, formed by covalent conjugation of AgAu@CeO2 with Lactobacillus reuteri) by anchoring an ultrasmall cerium dioxide (CeO2) nanozyme with peroxidase (POD)-like activity onto silver-gold nanocages (AgAu NCs), and integrating it with Lactobacillus reuteri (L. reuteri). Upon near-infrared light irradiation, the localized surface plasmon resonance effect of AgAu NCs induced dual regulatory mechanisms: photothermal heating, which elevated local temperature to enhance catalytic efficiency, and interfacial electron transfer, which promoted Ce3+/Ce4+ redox cycling to sustain catalytic activity. Simultaneously, L. reuteri modulated the local pH through the secretion of lactic and acetic acids, creating a favorable acidic microenvironment for enzyme function. This triple-modulation strategy markedly enhanced the POD-like activity of CeO2, triggering a robust reactive oxygen species burst that effectively disrupted periodontal biofilms and eliminated pathogenic bacteria. Furthermore, the composite interfered with microbial metabolic pathways, reducing biofilm formation and virulence. Our findings establish a powerful nanozyme-based platform for periodontitis treatment and provide a broadly applicable strategy for optimizing nanozyme performance in vivo. |
| 资助项目 | National Natural Science Foundation of China[82571148] ; National Natural Science Foundation of China[52572102] ; National Natural Science Foundation of China[82170998] ; Key Program of Natural Science Foundation of Jilin Province[20220204128YY] ; Interdisciplinary Innovative Team Project of Norman Bethune Health Science Department Jilin University[2025JBGS04] ; Interdisciplinary Innovative Team Project of Norman Bethune Health Science Department Jilin University[2024B36] ; Science and Technology Project of Jilin Province Financial Department[JCSZ2025678-4] ; Science and Technology Project of Jilin Province Financial Department[JCSZ2025678-11] ; Science and Technology Project of Jilin Province Financial Department[JCSZ2025678-15] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB0830300] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001587634900001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321627]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Sun, Jiao; Sun, Xiaolin; Cheng, Zhen; Wang, Lin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Jilin Univ, Hosp Stomatol, Dept Oral Implantol, Jilin Prov Key Lab Sci & Technol Stomatol Nanoengn, Changchun 130021, Peoples R China 4.Korea Univ, Dept Chem, Seoul 02841, South Korea 5.Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China 6.Jilin Univ, Coll Basic Med Sci, Dept Cell Biol, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Meiqi,Ding, Qihang,Hu, Songtao,et al. A triple-responsive nanozyme platform of AgAu-CeO2 heterojunction integrated with probiotics for precision antibacterial therapy in periodontitis[J]. BIOMATERIALS,2026,327:13. |
| APA | Li, Meiqi.,Ding, Qihang.,Hu, Songtao.,Qi, Manlin.,Sun, Jiao.,...&Wang, Lin.(2026).A triple-responsive nanozyme platform of AgAu-CeO2 heterojunction integrated with probiotics for precision antibacterial therapy in periodontitis.BIOMATERIALS,327,13. |
| MLA | Li, Meiqi,et al."A triple-responsive nanozyme platform of AgAu-CeO2 heterojunction integrated with probiotics for precision antibacterial therapy in periodontitis".BIOMATERIALS 327(2026):13. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。