A Reversible Chemoenzymatic Labeling Strategy for Profiling of Protein O-Glucosylation
文献类型：期刊论文
| 作者 | Zhang, Shilin2,3,4; Tian, Yinping2,3; Wang, Yuqiu1; Wei, Fangyu2,3,4; Zhou, Hu1,4; Wen, Liuqing2,3,4 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2025-10-11 |
| 页码 | 6 |
| 关键词 | Chemoenzymatic labeling Endoglycosidase Glycoproteomic O-Glc Protein glycosylation |
| DOI | 10.1002/anie.202513638 |
| 英文摘要 | O-linked glucose (O-Glc), the beta-linked modification of serine residues, is a rare form of protein glycosylation first identified on proteins containing epidermal growth factor (EGF)-like domains (canonical O-Glc). Several recent studies revealed that proteins lacking EGF-like domains could also undergo O-Glc modification (noncanonical O-Glc). However, the biosynthetic origin and biological function of protein O-glucosylation remain poorly understood and debated, owing to the lack of effective analytical tools. Here, a reversible chemoenzymatic labeling strategy for O-Glc analysis is described. By the strategy described, a large number of canonical and noncanonical O-Glc sites were identified in human cell lines, indicating that protein O-Glc is a widespread post-translational protein modification. |
| WOS关键词 | REPEATS |
| 资助项目 | Chinese Academy of Sciences |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001590874400001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321666]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Zhou, Hu; Wen, Liuqing |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shilin,Tian, Yinping,Wang, Yuqiu,et al. A Reversible Chemoenzymatic Labeling Strategy for Profiling of Protein O-Glucosylation[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2025:6. |
| APA | Zhang, Shilin,Tian, Yinping,Wang, Yuqiu,Wei, Fangyu,Zhou, Hu,&Wen, Liuqing.(2025).A Reversible Chemoenzymatic Labeling Strategy for Profiling of Protein O-Glucosylation.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6. |
| MLA | Zhang, Shilin,et al."A Reversible Chemoenzymatic Labeling Strategy for Profiling of Protein O-Glucosylation".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2025):6. |
入库方式： OAI收割
来源：上海药物研究所
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