Recent advances in DNA-encoded libraries: From covalent targeting to protein profiling
文献类型：期刊论文
| 作者 | Jin, Rui2; Lu, Xiaojie1,2 |
| 刊名 | CURRENT OPINION IN STRUCTURAL BIOLOGY
 |
| 出版日期 | 2025-12-01 |
| 卷号 | 95页码:9 |
| ISSN号 | 0959-440X |
| DOI | 10.1016/j.sbi.2025.103163 |
| 英文摘要 | DNA-encoded library (DEL) technology has enabled efficient covalent binders typically identified via covalent DELs developments have expanded CoDEL applications beyond cysteine to residues like lysine, tyrosine, arginine, and glutamic acid. The integration of CoDEL with activity-based protein profiling (ABPP) has further enabled the identification of potential protein targets for CoDEL screening using residueselective warheads. Additionally, proteome profiling with fullyfunctionalized tags has guided target identification for focused DELs with privileged structures. This review highlights recent advances in CoDEL technologies for targeting both cysteine and non-cysteine residues, and discusses how proteomics facilitates hit discovery through CoDELs and focused DELs. |
| WOS关键词 | DISCOVERY |
| 资助项目 | National Natural Science Foundation of China (NSFC)[22377139] ; National Natural Science Foundation of China (NSFC)[92253305] ; National Natural Science Foundation of China (NSFC)[22307131] ; Shanghai Action Plan for Science, Technology and Innovation[23HC1401200] ; Independent Project of Shanghai Institute of Materia Medica, Chinese Academy of Sciences[SIMM0220233001] ; National Key R&D Program of China[2024YFA1306003] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB0830000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB1260100] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001587719200001 |
| 出版者 | CURRENT BIOLOGY LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321669]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Lu, Xiaojie |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Rui,Lu, Xiaojie. Recent advances in DNA-encoded libraries: From covalent targeting to protein profiling[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY,2025,95:9. |
| APA | Jin, Rui,&Lu, Xiaojie.(2025).Recent advances in DNA-encoded libraries: From covalent targeting to protein profiling.CURRENT OPINION IN STRUCTURAL BIOLOGY,95,9. |
| MLA | Jin, Rui,et al."Recent advances in DNA-encoded libraries: From covalent targeting to protein profiling".CURRENT OPINION IN STRUCTURAL BIOLOGY 95(2025):9. |
入库方式： OAI收割
来源：上海药物研究所
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