Smart microneedles empowering programmable and sustained drug delivery
文献类型：期刊论文
| 作者 | Zeng, Weishu1,7; Ding, Qihang6; Zhang, Zhe4; Zhao, Jiaqi1; Ding, Xu1; Gao, Pengfei1; Chi, Minghan3; Qian, Kun2; Qi, Manlin1; Cheng, Zhen2,5 |
| 刊名 | COORDINATION CHEMISTRY REVIEWS
 |
| 出版日期 | 2026-02-01 |
| 卷号 | 548页码:28 |
| 关键词 | Microneedles Transdermal Drug Delivery Controlled Release Pharmacokinetics Stimuli-Responsive Systems Wound Management |
| ISSN号 | 0010-8545 |
| DOI | 10.1016/j.ccr.2025.217209 |
| 英文摘要 | Microneedles (MNs) have emerged as a promising platform for transdermal drug delivery, offering minimally invasive, programmable, and patient-friendly alternatives to conventional routes. Advances in fabrication and materials science have transformed MNs from simple metallic structures to multifunctional, biodegradable systems capable of dynamic drug release. This review analyzes MNs from the perspectives of structural design, material composition, and drug release kinetics. We examine key design parameters such as needle geometry and array configuration, and their effects on mechanical performance and delivery efficiency. MNs are categorized by type and functionality, highlighting innovations in tip design and backing layers for enhanced tissue penetration and payload control. A comparison of fabrication materials-including metals, inorganic nonmetals, natural and synthetic polymers-is presented, focusing on their degradation behavior and correlation with drug release timelines. Drug formulation strategies and pharmacokinetic models are also discussed, linking material-drug interactions to release profiles. Finally, recent applications in wound care, vaccination, hormone therapy, oncology, and ocular treatment are explored. This review bridges design, material, and pharmacokinetic considerations to support the development of next-generation MN systems with optimized spatiotemporal control for clinical applications. |
| WOS关键词 | DISSOLVING MICRONEEDLES ; RELEASE ; ARRAYS ; FORMULATIONS ; FABRICATION ; MECHANICS ; HYDROGEL ; VESICLES ; VACCINE ; PATCH |
| 资助项目 | National Science Foundation of China[82571148] ; National Science Foundation of China[82170998] ; International Cooperative Program of Natural Science Foundation of Jilin Province[20240402009GH] ; Bethune Program Project of Jilin University[2025JBGS04] ; Bethune Program Project of Jilin University[2024B36] ; Science and Technology Project of Jilin Province Financial Department[JCSZ2025678-4] ; Science and Technology Project of Jilin Province Financial Department[JCSZ2025678-11] ; Shandong Laboratory Program[SYS2e02205] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB0830300] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001594318300001 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321687]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Qi, Manlin; Cheng, Zhen; Wang, Lin |
| 作者单位 | 1.Jilin Univ, Hosp Stomatol, Dept Oral Implantol, Jilin Prov Key Lab Sci & Technol Stomatol Nanoengn, Changchun 130021, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Minnesota, Sch Dent, Malcom Moos Hlth Sci Tower, 515 Delaware St SE, Minneapolis, MN 55455 USA 4.Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 6.Korea Univ, Dept Chem, Seoul 02841, South Korea 7.Jilin Univ, Key Lab Pathobiol, Minist Educ, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Weishu,Ding, Qihang,Zhang, Zhe,et al. Smart microneedles empowering programmable and sustained drug delivery[J]. COORDINATION CHEMISTRY REVIEWS,2026,548:28. |
| APA | Zeng, Weishu.,Ding, Qihang.,Zhang, Zhe.,Zhao, Jiaqi.,Ding, Xu.,...&Wang, Lin.(2026).Smart microneedles empowering programmable and sustained drug delivery.COORDINATION CHEMISTRY REVIEWS,548,28. |
| MLA | Zeng, Weishu,et al."Smart microneedles empowering programmable and sustained drug delivery".COORDINATION CHEMISTRY REVIEWS 548(2026):28. |
入库方式： OAI收割
来源：上海药物研究所
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