Ru(II)- and Rh(III)-Catalyzed C-H Activation/Annulation of Pyrazolidinones with CF3-Imidoyl Sulfoxonium Ylides
文献类型：期刊论文
| 作者 | Kemelbek, Moldir2,4; Hu, Shulei1,4; Xiao, Qiannan1,4; Liu, Hong1,2,4; Wang, Jiang3,4 |
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2025-11-21 |
| 卷号 | 90期号:46页码:16360-16371 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.5c01727 |
| 英文摘要 | A catalytic system-controlled C-H activation and cascade annulation strategy for the synthesis of 5-substituted or 5,10-disubstituted pyrazolo[1,2-a]cinnolines is disclosed herein. A series of novel trifluoromethyl-substituted pyrazolo[1,2-a]cinnolines were successfully obtained utilizing a Ru(II)-catalyst and CF3-imidoyl sulfoxonium ylides. In the Rh(III)-catalytic system, 5-trifluoromethyl-10-enyl substituted pyrazolo[1,2-a]cinnolines were effectively constructed. Possible reaction mechanisms for the formation of both kinds of products were proposed based on preliminary mechanistic studies. These methods feature excellent regioselectivity, mild reaction conditions, broad substrate scope, operational simplicity, and facile product availability, providing practical access to structurally diverse pyrazolo[1,2-a]cinnolines. |
| 资助项目 | Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120225007] ; Program of Shanghai Academic Research Leader[23XD1460300] ; National Natural Science Foundation of China[22177124] ; National Key Research and Development Program of China[2022YFA1302900] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001612287900001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321694]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Liu, Hong; Wang, Jiang |
| 作者单位 | 1.China Pharmaceut Univ, Sch Sci, Nanjing 211198, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Lingang Lab, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kemelbek, Moldir,Hu, Shulei,Xiao, Qiannan,et al. Ru(II)- and Rh(III)-Catalyzed C-H Activation/Annulation of Pyrazolidinones with CF3-Imidoyl Sulfoxonium Ylides[J]. JOURNAL OF ORGANIC CHEMISTRY,2025,90(46):16360-16371. |
| APA | Kemelbek, Moldir,Hu, Shulei,Xiao, Qiannan,Liu, Hong,&Wang, Jiang.(2025).Ru(II)- and Rh(III)-Catalyzed C-H Activation/Annulation of Pyrazolidinones with CF3-Imidoyl Sulfoxonium Ylides.JOURNAL OF ORGANIC CHEMISTRY,90(46),16360-16371. |
| MLA | Kemelbek, Moldir,et al."Ru(II)- and Rh(III)-Catalyzed C-H Activation/Annulation of Pyrazolidinones with CF3-Imidoyl Sulfoxonium Ylides".JOURNAL OF ORGANIC CHEMISTRY 90.46(2025):16360-16371. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。