The distribution of Danqi tongmai tablet in rats at different timeframe by UHPLC-LTQ-orbitrap mass spectrometry and nanospray desorption electrospray ionization mass spectrometry imaging
文献类型：期刊论文
| 作者 | Dai, Chun-guang1,2; Li, Zhen-wei3; Wei, Wen-long1,4; Zhang, Jian-qing1,4; Bi, Qi-rui1,4; Zeng, Rui2; Guo, De-an1,3,4 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2026 |
| 卷号 | 188页码:9 |
| 关键词 | Danqi Tongmai tablet Tissues distribution in vivo Nanospray desorption electrospray ionization mass spectrometry imaging Spatial distribution Mass spectral tree similarity filter |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2025.106942 |
| 通讯作者 | Guo, De-an(daguo@shutcm.edu.cn) |
| 英文摘要 | Danqi Tongmai tablet (DQTM), a combination of salvianolic acids (SA) and panax notoginsenosides (PNS), is developed for the treatment of cardiovascular diseases. However, the distribution of DQTM in vivo remained unclear. In the present study, a four-step approach was developed and applied for elucidating the migration of chemical constituents from DQTM to rat plasma and tissues. Firstly, the chemical components in DQTM were comprehensively characterized based on mass spectral tree similarity filter (MTSF) technique on LTQ-Orbitrap mass spectrometry. Secondly, the main chemical constituents absorbed into blood were identified with reference standards. Thirdly, the chemical constituents distributed in different tissues were characterized. Fourthly, the spatial distribution of main notoginsenosides in different tissues were explored by nano-spray desorption electrospray ionization mass spectrometry imaging (DESI-MSI), and the results of different administration methods were compared. As a result, 209 chemical constituents in DQTM were tentatively characterized, including 103 salvianolic acids and 106 notoginsenosides. Forty-two chemical constituents were unambiguously identified with reference standards in plasma. Meanwhile, 42 components in kidney, 40 in lung, 37 in heart, 38 in liver and spleen, and 30 in brain were identified. The results of DESI-MSI showed that notoginsenosides were primarily distributed in kidney, and slightly accumulated in brain, liver, lung, spleen and heart. Notoginsenosides were mainly distributed in the renal pelvis, and excreted at 1 h approximately after intravenous administration. In addition, there was no obvious accumulation effect between single dose and successive oral administration. |
| WOS关键词 | SALVIA-MILTIORRHIZA ; TISSUE DISTRIBUTION ; ACIDS ; NOTOGINSENGNOSIDES ; IDENTIFICATION ; METABOLITES ; EXCRETION ; PLASMA ; MS |
| 资助项目 | SIMM-National Engineering Research Center of TCM Standardization Technology independent research program[2024-ZYBZH-07] ; Key Program of National Natural Science Foundation of China[82130111] ; Fundamental Research Funds for the Central Universities. Southwest Minzu University[ZYN2024156] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001616352800001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321699]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China 2.Southwest Minzu Univ, Coll Pharm & Food, Chengdu 610225, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Shanghai Acad Int Standardizat Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Chun-guang,Li, Zhen-wei,Wei, Wen-long,et al. The distribution of Danqi tongmai tablet in rats at different timeframe by UHPLC-LTQ-orbitrap mass spectrometry and nanospray desorption electrospray ionization mass spectrometry imaging[J]. FITOTERAPIA,2026,188:9. |
| APA | Dai, Chun-guang.,Li, Zhen-wei.,Wei, Wen-long.,Zhang, Jian-qing.,Bi, Qi-rui.,...&Guo, De-an.(2026).The distribution of Danqi tongmai tablet in rats at different timeframe by UHPLC-LTQ-orbitrap mass spectrometry and nanospray desorption electrospray ionization mass spectrometry imaging.FITOTERAPIA,188,9. |
| MLA | Dai, Chun-guang,et al."The distribution of Danqi tongmai tablet in rats at different timeframe by UHPLC-LTQ-orbitrap mass spectrometry and nanospray desorption electrospray ionization mass spectrometry imaging".FITOTERAPIA 188(2026):9. |
入库方式： OAI收割
来源：上海药物研究所
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