Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine Nocardiopsis spp.
文献类型：期刊论文
| 作者 | Xu, Quan2,3; Yan, Bing-Yuan2; Wang, Hui-Fang2; Wu, Qiong2; Li, Xu-Wen1,2; Zhang, Xiangyang3 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2025-11-17 |
| 页码 | 9 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.5c01038 |
| 通讯作者 | Li, Xu-Wen(xwli@simm.ac.cn) ; Zhang, Xiangyang(xiangyang.zhang@tju.edu.cn) |
| 英文摘要 | We report the divergent total synthesis of marine natural products nocarterphenyl A (1), 2-dehydroxymethylnocarterphenyl A (2), and nocarterphenyl D (3). The thiazole-fused p-terphenyl core was synthesized via Suzuki-Miyaura coupling, and dibrominated precursor 6 was obtained by dibromination of a multisubstituted benzothiazole 7 using NBS/morpholine/HFIP. Nocarterphenyl D (3) was synthesized through palladium-catalyzed dehydrogenation cross-coupling. Biological evaluation revealed that nocarterphenyl A (1) inhibited HCT116 cell proliferation by 71% at 10 mu M. Preliminary structure-activity relationships are discussed. |
| WOS关键词 | P-TERPHENYL DERIVATIVES ; BENZOTHIAZOLES ; LIGAND |
| 资助项目 | Fundamental Research Projects of Science & Technology Innovation and Development Plan in Yantai City[2023JCYJ057] ; Chinese Academy of Sciences[XDB1060000] ; Taishan Scholar Project of Shandong Province[tsqn2023-12302] ; Key Technology Research and Development Program of Shandong Province[2024CXPT028] ; National Natural Science Foundation of China[82022069] ; Shandong Laboratory Program[SYS202205] ; National Key Research and Development Program of China[2021YFF0502400] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001617226300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321713]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Xu-Wen; Zhang, Xiangyang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 3.Tianjin Univ, Fac Med, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Quan,Yan, Bing-Yuan,Wang, Hui-Fang,et al. Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine Nocardiopsis spp.[J]. JOURNAL OF NATURAL PRODUCTS,2025:9. |
| APA | Xu, Quan,Yan, Bing-Yuan,Wang, Hui-Fang,Wu, Qiong,Li, Xu-Wen,&Zhang, Xiangyang.(2025).Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine Nocardiopsis spp..JOURNAL OF NATURAL PRODUCTS,9. |
| MLA | Xu, Quan,et al."Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine Nocardiopsis spp.".JOURNAL OF NATURAL PRODUCTS (2025):9. |
入库方式： OAI收割
来源：上海药物研究所
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