中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 国家级研究中心
  5. 原创新药研究全国重点实验室
Previously undescribed isoflavan-stilbene dimers from the roots of Sophora davidii (Franch.) skeels and their glucose transporter 4 translocation activities

文献类型：期刊论文

作者Yu, Ruitao1; Kang, Shiwen4; Ma, Yuanren4; Cheng, Haitao4; Chen, Jinghua1; Tao, Yanduo1; Xiong, Wei3; Yang, Xinzhou1,2,4
刊名PHYTOCHEMISTRY
出版日期2026-02-01
卷号242页码:11
关键词Sophora davidii Leguminosae Isoflavan Stilbene Antidiabetic GLUT-4 ECD
ISSN号0031-9422
DOI10.1016/j.phytochem.2025.114715
英文摘要Eight previously undescribed compounds, davidinins B-G (1-4, 5a, 5b, 6a and 6b), including two sets of enantiomeric pairs (5a/5b and 6a/6b) together with six known compounds, were isolated from the ethyl acetate fractions of the roots of Sophora davidii (Franch.) Skeels. Using chiral HPLC, the enantiomers (+)-(3R,4R)-davidinin F (5a), (-)-(3S,4S)-davidinin F (5b), (+)-(R)-davidinin G (6a), and (-)-(S)-davidinin G (6b) were successfully separated and obtained. Their planer structures were established through analysis of 1D and 2D NMR and HRESIMS data. The absolute configurations of the previously undescribed compounds were mainly determined by NMR calculation and electronic circular dichroism (ECD) calculation. At a concentration of 20 mu g/mL, compounds 1-4, 5a, 5b, 6a, 6b, and 7-9 modulated GLUT4 translocation to 1.15-2.47-fold of the control; among them, compound 4 exhibited the strongest increase.
资助项目Qinghai Province Central Government Guides Local Science and Technology Development Fund[2025ZY014] ; National Natural Science Foundation of China[82374144] ; Fundamental Research Funds for the Central Universities, South-Central MinZu University[CZD24003] ; Fundamental Research Funds for the Central Universities, South-Central MinZu University[XTZ24026] ; State Key Laboratory of Drug Research[SKLDR-2024-KF-05] ; Tianchi Talent-Distinguished Professor Program
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:001612205900001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/321762]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Xiong, Wei; Yang, Xinzhou
作者单位1.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201201, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430030, Peoples R China
4.South Cent Minzu Univ, Sch Pharmaceut Sci, Int Cooperat Base Act Subst Tradit Chinese Med Hub, 182 Minzu Rd, Wuhan 430074, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Ruitao,Kang, Shiwen,Ma, Yuanren,et al. Previously undescribed isoflavan-stilbene dimers from the roots of Sophora davidii (Franch.) skeels and their glucose transporter 4 translocation activities[J]. PHYTOCHEMISTRY,2026,242:11.
APA Yu, Ruitao.,Kang, Shiwen.,Ma, Yuanren.,Cheng, Haitao.,Chen, Jinghua.,...&Yang, Xinzhou.(2026).Previously undescribed isoflavan-stilbene dimers from the roots of Sophora davidii (Franch.) skeels and their glucose transporter 4 translocation activities.PHYTOCHEMISTRY,242,11.
MLA Yu, Ruitao,et al."Previously undescribed isoflavan-stilbene dimers from the roots of Sophora davidii (Franch.) skeels and their glucose transporter 4 translocation activities".PHYTOCHEMISTRY 242(2026):11.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。