Preparation and characterization of grafted imprinted monolith for capillary electrochromatography
文献类型：期刊论文
| 作者 | Wei Ze-Hui; Mu Li-Na; Pang Qian-Qian; Huang Yan-Ping; Liu Zhao-Sheng |
| 刊名 | ELECTROPHORESIS
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:19-20页码:3021-3027 |
| 关键词 | CEC Chiral separation Graft polymerization Molecularly imprinted polymer Monolithic column |
| ISSN号 | 0173-0835 |
| 英文摘要 | In this paper, a molecularly imprinted polymer (MIP) coating grafted to a trimethylolpropane trimethacrylate (TRIM) core material for CEC was reported. The core monolith was prepared with a solution of 20% (w/w) TRIM in a mixture of porogen and a polymerization precursor, which can generate a stable electroosmotic flow due to the formation of ionizable groups after postpolymerization hydrolization. Graft polymerization took place on the resultant TRIM monolith with a mixture of template, methacrylic acid, and ethylene glycol dimethacrylate. Strong recognition ability (selectivity factor was 5.83) for S-amlodipine and resolution of enatiomers separation (up to 7.99) were obtained on the resulting grafted imprinted monolith in CEC mode. The influence of CEC conditions on chiral separation, including the composition of mobile phase, pH value, and the operating voltages was studied. These results suggest that the method of grafted polymerization reported here allows a rapid development of MIP monolith once core materials with desired properties are available, and is a good alternative to prepare CEC-based monolithic MIPs. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000310289600011 |
| 公开日期 | 2013-11-07 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/2763]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
| 作者单位 | Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Xinjiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei Ze-Hui,Mu Li-Na,Pang Qian-Qian,et al. Preparation and characterization of grafted imprinted monolith for capillary electrochromatography[J]. ELECTROPHORESIS,2012,33(19-20):3021-3027. |
| APA | Wei Ze-Hui,Mu Li-Na,Pang Qian-Qian,Huang Yan-Ping,&Liu Zhao-Sheng.(2012).Preparation and characterization of grafted imprinted monolith for capillary electrochromatography.ELECTROPHORESIS,33(19-20),3021-3027. |
| MLA | Wei Ze-Hui,et al."Preparation and characterization of grafted imprinted monolith for capillary electrochromatography".ELECTROPHORESIS 33.19-20(2012):3021-3027. |
入库方式： OAI收割
来源：新疆理化技术研究所
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