Trimerization-Enhanced NIR-II/Photoacoustic Nanoprobes for Precision Osteosarcoma Imaging
文献类型：期刊论文
| 作者 | Lu, Siyu5; Wu, Jing4,5; Lyu, Shuxin1; Yu, Yifeng5; Kim, Jong Seung6; Zhang, Ruiping1; Xiao, Yuling2,3,4,7; Hong, Xuechuan2,3,4,5,7; Zeng, Xiaodong2,3,5,7 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2025-11-25 |
| 卷号 | 97期号:46页码:25701-25711 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.5c05017 |
| 英文摘要 | The integration of photoacoustic imaging (PAI) and near-infrared II (NIR-II) fluorescence imaging holds transformative potential for cancer diagnostics but faces challenges in developing high-performance dual-modal contrast agents. We report tH7@CT8, an organic nanoprobe engineered through fluorophore trimerization to address the photothermal conversion efficiency limitations of small-molecule agents. Trimerization of the [1,2,5]thiadiazolo[3,4-g]quinoxaline fluorophore derivative H7 induced aggregation, suppressing fluorescence quantum yield (0.11% vs 0.42% monomer) while amplifying PTCE to 43.1%. Encapsulation within an osteosarcoma-targeting amphiphilic matrix yielded nanoparticles (72 +/- 19 nm) with 4-fold enhanced tumor uptake versus nontargeted controls. In orthotopic osteosarcoma models, tH7@CT8 enabled PAI detection and real-time NIR-II guidance with signal (tumor)-to-background ratios >12:1. This work establishes a molecular design strategy to reconcile depth-resolution trade-offs in oncology while advancing organic contrast agents toward clinical translation. |
| WOS关键词 | PHOTOACOUSTIC PROBES ; DYE |
| 资助项目 | Shenzhen Science and Technology Innovation Program[JCYJ20220530140605012] ; Science and Technology Planning Project of Lhasa[LSKJ202445] ; Natural Science Foundation of Shandong Province[ZR2023MB085] ; Basic and Applied Basic Research Foundation of Guangdong Province[2023A1515012649] ; National Natural Science Foundation of China[22477129] ; Shandong Laboratory Program[SYS202205] ; Interdisciplinary Innovative Foundation of Zhongnan Hospital[ZNJC202413] ; Special Supporting Funds for Leading Talents at or above the Provincial Level in Yantai[NA] ; National Key Research and Development Program of China[2023YFC3402800] ; Key Laboratory of Nano-imaging and Drug-loaded Preparation of Shanxi Province[202104010910010] ; Taishan Scholar Foundation of Shandong Province[TSQN202306320] ; Science and Technology Plan Projects of Tibet Autonomous Region[XZ202301ZY0014G] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001615897800001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321776]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Zhang, Ruiping; Xiao, Yuling; Hong, Xuechuan; Zeng, Xiaodong |
| 作者单位 | 1.Shanxi Med Univ, Shanxi Prov Peoples Hosp, Hosp 5, Taiyuan, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China 5.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Radiol, Wuhan 430071, Peoples R China 6.Korea Univ, Dept Chem, Seoul 02841, South Korea 7.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Siyu,Wu, Jing,Lyu, Shuxin,et al. Trimerization-Enhanced NIR-II/Photoacoustic Nanoprobes for Precision Osteosarcoma Imaging[J]. ANALYTICAL CHEMISTRY,2025,97(46):25701-25711. |
| APA | Lu, Siyu.,Wu, Jing.,Lyu, Shuxin.,Yu, Yifeng.,Kim, Jong Seung.,...&Zeng, Xiaodong.(2025).Trimerization-Enhanced NIR-II/Photoacoustic Nanoprobes for Precision Osteosarcoma Imaging.ANALYTICAL CHEMISTRY,97(46),25701-25711. |
| MLA | Lu, Siyu,et al."Trimerization-Enhanced NIR-II/Photoacoustic Nanoprobes for Precision Osteosarcoma Imaging".ANALYTICAL CHEMISTRY 97.46(2025):25701-25711. |
入库方式： OAI收割
来源：上海药物研究所
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