Deciphering the Distinct Vascular Liver Injury Induced by Pyrrolizidine Alkaloids: From the Invasive Species to Health Hazard
文献类型：期刊论文
| 作者 | Huang, Tianyang4; Song, Zijing3; Zhang, Caibin4; Guo, Xiaokai4; Ma, Jiang1; Zhang, Chengliang2; He, Yisheng4 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2025-11-24 |
| 页码 | 16 |
| 关键词 | emerging contaminants pyrrolizidine alkaloids invasive species health hazard liver toxicity |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.5c09270 |
| 通讯作者 | He, Yisheng(heyisheng@cuhk.edu.cn) |
| 英文摘要 | Pyrrolizidine alkaloids (PAs) are the most common plant-derived toxins present in numerous herbal and food products, but their environmental transfer pathways and toxicological mechanisms remain unclear. This study establishes a complete contamination pathway from environmental source to molecular target. We identified the invasive plant Bidens alba as a novel PA producer and provided the first evidence of transfer to honey by detecting corresponding PAs and characteristic Bidens alba pollens in local samples. Mechanistically, we demonstrated that PA toxicity fundamentally differs from classic hepatotoxins like acetaminophen. Instead of directly damaging liver cells, PAs first induce red blood cell rupture (hemolysis) by selectively inhibiting glucose-6-phosphate dehydrogenase (G6PD). This hemolytic event precedes observable liver sinusoidal endothelial damage and initiates characteristic vascular liver injury. Our findings establish a new route of food contamination and redefine PA toxicity by identifying blood cells as the primary target, with significant implications for food safety and public health. |
| WOS关键词 | HEPATIC VENOOCCLUSIVE DISEASE ; ACETAMINOPHEN HEPATOTOXICITY ; METABOLIC-ACTIVATION ; PLANTS ; HONEY |
| 资助项目 | Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20240813113552066] ; Basic and Applied Basic Research Foundation of Guangdong Province[2022A1515110678] ; National Natural Science Foundation of China[82474179] ; Hospital University United Fund of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen[HUUF-MS-202301] |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:001621943200001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322004]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | He, Yisheng |
| 作者单位 | 1.Guangdong Pharmaceut Univ, Sch Chinese Mat Med, Guangzhou 510006, Guangdong, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528454, Guangdong, Peoples R China 4.Chinese Univ Hong Kong, Sch Med, Shenzhen 518172, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Tianyang,Song, Zijing,Zhang, Caibin,et al. Deciphering the Distinct Vascular Liver Injury Induced by Pyrrolizidine Alkaloids: From the Invasive Species to Health Hazard[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2025:16. |
| APA | Huang, Tianyang.,Song, Zijing.,Zhang, Caibin.,Guo, Xiaokai.,Ma, Jiang.,...&He, Yisheng.(2025).Deciphering the Distinct Vascular Liver Injury Induced by Pyrrolizidine Alkaloids: From the Invasive Species to Health Hazard.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,16. |
| MLA | Huang, Tianyang,et al."Deciphering the Distinct Vascular Liver Injury Induced by Pyrrolizidine Alkaloids: From the Invasive Species to Health Hazard".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2025):16. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。