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Twisted intramolecular charge transfer (TICT) based fluorescent probes and imaging agents

文献类型：期刊论文

作者Wu, Yueci5,6; Wang, Han-Min1,4,7; Hu, Xi-Le2,3; Zang, Yi9; Li, Jia1,4,7; Han, Hai-Hao1,4,7; He, Xiao-Peng2,3,8; Lewis, Simon E.6; Ismail, Hanafy M.5; James, Tony D.6,10
刊名CHEMICAL SOCIETY REVIEWS
出版日期2025-12-08
卷号54期号:24页码:12080-12141
ISSN号0306-0012
DOI10.1039/d3cs01118f
通讯作者Li, Jia(jli@simm.ac.cn) ; Han, Hai-Hao(hanhaihao@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; Lewis, Simon E.(s.e.lewis@bath.ac.uk) ; Ismail, Hanafy M.(hanafy.ismail@lstmed.ac.uk) ; James, Tony D.(t.d.james@bath.ac.uk)
英文摘要Twisted Intramolecular charge transfer (TICT)-based fluorescent probes are crucial in chemical sensing due to their sensitivity and specificity. These probes undergo conformational changes upon interacting with target analytes, resulting in measurable fluorescence responses. Their environment-dependent emission characteristics make them ideal for detecting variations in solvent polarity, microviscosity, and specific chemical species. Recent advances have expanded their applications to organic optoelectronics and non-linear optics. This review discusses the design principles, mechanisms, and applications of TICT-based probes, emphasizing their role in detecting cations, anions, and neutral molecules. We describe their advantages, such as fluorescence turn-on or turn-off responses and potential for ratiometric detection, which inherently corrects for interferences. Challenges in developing these probes, including fluorescence quantum yield and photostability, are also addressed. Potential directions for future research are highlighted, including the need for improved biocompatibility and multimodal imaging capabilities, with the aim of enhancing their utility in environmental monitoring, biomedical research, and clinical diagnostics.
WOS关键词HUMAN SERUM-ALBUMIN ; AGGREGATION-INDUCED EMISSION ; HEPATOCYTE-LIKE CELLS ; SENSITIVE DETECTION ; HYDROGEN-PEROXIDE ; NAPHTHALENE DIIMIDE ; SELECTIVE DETECTION ; ALZHEIMERS-DISEASE ; HYPOCHLOROUS ACID ; OXIDATIVE STRESS
资助项目University of Bath ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01] ; EPSRC[EP/W036193/1] ; National Natural Science Foundation of China[2377135] ; National Natural Science Foundation of China[22107029] ; National Natural Science Foundation of China[92253306] ; National Natural Science Foundation of China[22477030] ; Key R&D Program of Shandong[2024CXPT028] ; Shandong Laboratory Program[SYS202205] ; Taishan Scholars Program[tsqn202312305] ; Young Elite Scientists Sponsorship Program by Chinese Chemical Society ; Fundamental Research Projects of Science & Technology Innovation and development Plan in Yantai City[2023JCYJ059] ; Science and Technology Commission of Shanghai Municipality[24DX1400200] ; International Cooperation Program of Shanghai Science and Technology[23490711600] ; Shanghai Oriental Talents youth Program[QNKJ2024010] ; Shanghai Xuhui District Hospital Local Cooperation Project[23XHYD-20] ; Open Funding Project of the State Key Laboratory of Fine Chemicals, Dalian University of Technology[KF 2402] ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; Open Funding Project of the State Key Laboratory of Bioreactor Engineering, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, P.R. China ; Ministry of Education Key Laboratory on signaling Regulation and Targeting Therapy of Liver Cancer (Naval Medical University)[2023-MEKLLC-MS/ZD-00*] ; State Key Laboratory of Drug Research[SKLDR-2025-KF-09]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001619744600001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/322034]  
专题中国科学院上海药物研究所
通讯作者Li, Jia; Han, Hai-Hao; He, Xiao-Peng; Lewis, Simon E.; Ismail, Hanafy M.; James, Tony D.
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Stake Key Lab Chem Biol,Mol Imaging Ctr, Shanghai 201203, Peoples R China
2.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China
3.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
5.Univ Liverpool Liverpool Sch Trop Med, Vector Biol, Liverpool L3 5QA, England
6.Univ Bath, Dept Chem, Bath BA2 7AY, England
7.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
8.Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China
9.Lingang Lab, Shanghai 201203, Peoples R China
10.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Yueci,Wang, Han-Min,Hu, Xi-Le,et al. Twisted intramolecular charge transfer (TICT) based fluorescent probes and imaging agents[J]. CHEMICAL SOCIETY REVIEWS,2025,54(24):12080-12141.
APA Wu, Yueci.,Wang, Han-Min.,Hu, Xi-Le.,Zang, Yi.,Li, Jia.,...&James, Tony D..(2025).Twisted intramolecular charge transfer (TICT) based fluorescent probes and imaging agents.CHEMICAL SOCIETY REVIEWS,54(24),12080-12141.
MLA Wu, Yueci,et al."Twisted intramolecular charge transfer (TICT) based fluorescent probes and imaging agents".CHEMICAL SOCIETY REVIEWS 54.24(2025):12080-12141.

入库方式： OAI收割

来源：上海药物研究所

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