The anti-aging potential of VA'S new derivatives through metabolomic profiling
文献类型：期刊论文
| 作者 | Tan, Li2; Wu, Jiang3; Wang, Jiewen2; Zhang, Hongkang2; Zhang, Wei3; Gao, Ang3; Zhong, Zhijian1; Chen, Tie-gen1; Zhou, Baoping3; Han, Tengfei3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2025-11-27 |
| 卷号 | 15期号:1页码:14 |
| 关键词 | MVA Metabolomics Anti-aging Molecular synthesis |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-025-25545-9 |
| 通讯作者 | Wu, Jiang(johnnywu@coachchem.com) ; Fan, Zhenxin(zxfan@scu.edu.cn) ; Zhou, Ya(zhouya@ibt.pumc.edu.cn) |
| 英文摘要 | Skin aging is a complex process influenced by intrinsic and extrinsic factors, leading to structural and functional changes such as reduced elasticity and increased wrinkles. This study aims to evaluate the potential biological functions of Magic vitamin A (MVA) in skin health management and skin aging through metabolomics analysis. We performed untargeted metabolomics analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to explore the changes in metabolites and related metabolic pathways induced by MVA in HaCaT cells. This suggests that MVA treatment substantially alters the cellular metabolic state. The boxplot analysis indicates that MVA altered the levels of several metabolites, including 18-beta-Glycyrrhetinic acid, Palmitoylethanolamide (PEA), 17-AAG, l-arginine, and Dehydroepiandrosterone (DHEA), all of which exhibit significant biological effects in anti-aging, anti-inflammatory, and antioxidant properties. Additionally, key metabolic pathways, such as Arginine and proline metabolism, Purine metabolism, and Arachidonic acid metabolism, also highlighted potential anti-aging pathways of MVA. Our findings suggest that MVA may improve skin health through multiple metabolic mechanisms, supporting its potential as an anti-aging agent. |
| WOS关键词 | 18-BETA-GLYCYRRHETINIC ACID ; PALMITOYLETHANOLAMIDE ; RETINOIDS ; ACTIVATION ; EFFICACY ; SAFETY ; CELLS ; NRF2 |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001629328300004 |
| 出版者 | NATURE PORTFOLIO |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322055]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Jiang; Fan, Zhenxin; Zhou, Ya |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Sichuan Univ, Coll Life Sci, Conservat Endangered Wildlife Key Lab Sichuan Prov, Chengdu, Peoples R China 3.Shanghai Coachchem Technol, Shanghai, Peoples R China 4.Chinese Acad Med Sci, Inst Blood Transfus, Chengdu, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Li,Wu, Jiang,Wang, Jiewen,et al. The anti-aging potential of VA'S new derivatives through metabolomic profiling[J]. SCIENTIFIC REPORTS,2025,15(1):14. |
| APA | Tan, Li.,Wu, Jiang.,Wang, Jiewen.,Zhang, Hongkang.,Zhang, Wei.,...&Zhou, Ya.(2025).The anti-aging potential of VA'S new derivatives through metabolomic profiling.SCIENTIFIC REPORTS,15(1),14. |
| MLA | Tan, Li,et al."The anti-aging potential of VA'S new derivatives through metabolomic profiling".SCIENTIFIC REPORTS 15.1(2025):14. |
入库方式： OAI收割
来源：上海药物研究所
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