Multiomic Analysis of Candida albicans Adaptation during Commensal Coexistence with Staphylococcus aureus
文献类型：期刊论文
| 作者 | Zhou, Changxia1,4; Wang, Jingling4; Wei, Shenkun1,4; Hu, Zunli4; Liu, Xia4; Tian, Dabang1,4; Zhu, Wenhan4; Tan, Minjia1,3,4; Xu, Jun-Yu1,2,3,4 |
| 刊名 | ACS CHEMICAL BIOLOGY
 |
| 出版日期 | 2025-11-26 |
| 页码 | 13 |
| ISSN号 | 1554-8929 |
| DOI | 10.1021/acschembio.5c00681 |
| 英文摘要 | Candida albicans (C. albicans) is a conditionally pathogenic fungus in humans, with its virulence significantly modulated by alterations in the composition of commensal bacteria and the surrounding microecological environment, particularly during cohabitation with methicillin-resistant Staphylococcus aureus (MRSA). Despite this, the molecular mechanisms underlying these interactions remain inadequately elucidated. In this study, we utilized an integrative multiomics approach, including proteomics and proteomics of post-translational modifications (PTMs), to systematically examine the impact of MRSA on protein expression and PTM patterns in C. albicans. Our findings indicate that the presence of MRSA markedly influenced the expression of virulence-associated proteins and modified the phosphorylation and acetylation levels of key proteins involved in essential signaling and metabolic pathways. These modifications were predominantly associated with biological processes such as energy metabolism, metabolic reprogramming, and stress response. Functional enrichment analyses further indicated that these PTMs may play crucial roles in regulating the pathogenicity and environmental adaptability of C. albicans. Moreover, in vitro enzyme activity assays revealed that lysine acetylation induced by MRSA modulated the activities of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and homoisocitrate dehydrogenase (HIcDH). This suggests that such modifications are involved in the metabolic adaptation and functional reprogramming of C. albicans. In conclusion, this study provides novel insights into the regulation of fungal physiology mediated by MRSA through PTMs, thereby offering a new theoretical framework for understanding fungal pathogenesis and for the development of enhanced anti-infective strategies within the context of bacterial-fungal interactions. |
| WOS关键词 | PROTEIN POSTTRANSLATIONAL MODIFICATIONS ; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE ; SYSTEMATIC ANALYSIS ; LYSINE ACETYLOME ; VIRULENCE |
| 资助项目 | Innovative Research Team of High-level Local University in Shanghai[SHSMU-ZDCX20212700] ; Program of Shanghai Academic Research Leader[22XD1420900] ; Guangdong High-level New RD Institute[2019B090904008] ; National Natural Science Foundation of China[22225702] ; Youth Innovation Promotion Association[CAS2021276] ; Shanghai Rising-Star Program[22QA1411100] ; Guangdong High-level Innovative Research Institute[2021B0909050003] ; National Key Research and Development Program of China[2023YFA1800403] ; Zhongshan Science and Technology Bureau[CXTD2024006] ; Sanofi[NA] ; China Association for Science and Technology[2022QNRC001] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001626049600001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322058]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Tan, Minjia; Xu, Jun-Yu |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai Key Lab Gene Editing & Cell Based Immunot, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Changxia,Wang, Jingling,Wei, Shenkun,et al. Multiomic Analysis of Candida albicans Adaptation during Commensal Coexistence with Staphylococcus aureus[J]. ACS CHEMICAL BIOLOGY,2025:13. |
| APA | Zhou, Changxia.,Wang, Jingling.,Wei, Shenkun.,Hu, Zunli.,Liu, Xia.,...&Xu, Jun-Yu.(2025).Multiomic Analysis of Candida albicans Adaptation during Commensal Coexistence with Staphylococcus aureus.ACS CHEMICAL BIOLOGY,13. |
| MLA | Zhou, Changxia,et al."Multiomic Analysis of Candida albicans Adaptation during Commensal Coexistence with Staphylococcus aureus".ACS CHEMICAL BIOLOGY (2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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