Isolation of two novel terpenoid skeletons from Croton laui, an aromatic norsesterterpenoid and a highly rearranged neo-clerodane diterpenoid
文献类型：期刊论文
| 作者 | Zhang, Zong-Yi1,3; Wang, Xin1,2; Li, Ying2; Gao, Yuan3; Fan, Yao-Yue1,2,3; Yue, Jian-Min1,2,3; Zhao, Jin-Xin1,2,3 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2026-02-01 |
| 卷号 | 37期号:2页码:5 |
| 关键词 | Croton laui Sesterterpenoid Diterpenoid Multidrug resistance reversal Anti-adipogenesis |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2025.110951 |
| 英文摘要 | New-skeleton terpenoids have prompted considerable interest owing to their chemical and biological significance. A chemical study on the bark of Croton laui led to the isolation and identification of a new norsesterterpenoid, crolatinoid A ( 1 ), and two new neoclerodane diterpenoids, crolatinoids B and C ( 2 and 3 ). Structurally, compound 1 exhibits an unprecedented 12,17-cyclo20-nor phenyllabdane skeleton. Compound 2 features a novel 19(5 -> 4)-abeo-3,5-cycloneoclerodane skeleton, which is hypothetically derived from precursor 3 through an oxa-di- pi-methane rearrangement process. Furthermore, compound 1 demonstrated a significant capacity to reverse multidrug resistance in paclitaxel-resistant HCT-15 cells with a reversal fold value of 16. All three compounds displayed adipogenesis inhibition in 3T3-L1 adipocytes. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
| WOS关键词 | ELECTRONIC CIRCULAR-DICHROISM ; SESTERTERPENOIDS ; ADIPOGENESIS ; SYSTEM |
| 资助项目 | National Key Research and Development Program of China[2023YFE0206100] ; National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[T2192972] ; Youth Innovation Promotion Association of Chinese Academy of Sciences (CAS)[2022282] ; Shanghai Institute of Materia Medica of CAS[SIMM0120231002] ; Hainan University, People's Republic of China |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001625246100005 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322064]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Yue, Jian-Min; Zhao, Jin-Xin |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ethnomed & Biofunct Mol Res Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zong-Yi,Wang, Xin,Li, Ying,et al. Isolation of two novel terpenoid skeletons from Croton laui, an aromatic norsesterterpenoid and a highly rearranged neo-clerodane diterpenoid[J]. CHINESE CHEMICAL LETTERS,2026,37(2):5. |
| APA | Zhang, Zong-Yi.,Wang, Xin.,Li, Ying.,Gao, Yuan.,Fan, Yao-Yue.,...&Zhao, Jin-Xin.(2026).Isolation of two novel terpenoid skeletons from Croton laui, an aromatic norsesterterpenoid and a highly rearranged neo-clerodane diterpenoid.CHINESE CHEMICAL LETTERS,37(2),5. |
| MLA | Zhang, Zong-Yi,et al."Isolation of two novel terpenoid skeletons from Croton laui, an aromatic norsesterterpenoid and a highly rearranged neo-clerodane diterpenoid".CHINESE CHEMICAL LETTERS 37.2(2026):5. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。