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Diverse C-H Activation in Asymmetric Multicomponent Coupling: Unlocking Anti-Parkinson Pseudo-Natural Macrocycles

文献类型：期刊论文

作者Ma, Xiaolong4,5; Qi, Li-Feng-Rong6; Wu, Yufeng7; Liu, Shuai1; Liu, Xiujuan4,5; Wang, Han4,5; Li, Jia3,4,5,8; Xu, Xiaojun1; Yang, Weibo2,5,8
刊名ACS CATALYSIS
出版日期2025-11-26
页码11
关键词C-H activation asymmetricmulticomponent coupling macrocyclization pseudo-naturalmacrocycles anti-Parkinson's disease
ISSN号2155-5435
DOI10.1021/acscatal.5c06515
英文摘要The development of the multicomponent coupling of diverse C-H bonds to rapidly construct complex molecules has been highly appealing in the chemistry community. However, making such asymmetric processes is highly challenging due to the inherent difficulty in the activity and selectivity. Here, we describe a Rh(III)-catalyzed asymmetric multicomponent coupling involving diversified C(sp3)-H and C(sp2)-H activation. The asymmetric process is facilitated by a combined ex situ and in situ amide formed directing group-assisted chiral Rh(III) catalyst strategy. This strategy is distinctive for its capacity to expeditiously convert a variety of aliphatic C-H bonds of oximes, N-heterocycles, and C-H of aromatic compounds with maleimides in a highly chemo-selective and diversified chiral controllable manner. Moreover, the synthetic utility of this asymmetric multicomponent coupling is exemplified by the efficient and enantioselective synthesis of pseudo-natural macrocyclic oxime ( S )-YWB0337. This compound demonstrated promising efficacy in the clearance of alpha-synuclein aggregates associated with Parkinson's disease (PD).
WOS关键词ATROPISOMERISM ; CATALYSIS
资助项目Chinese Academy of Sciences[XDB0830000] ; National Natural Science Foundation of China[22171275]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001624926900001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/322082]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Li, Jia; Xu, Xiaojun; Yang, Weibo
作者单位1.Zhejiang Univ, Int Inst Med, Ctr Innovat Tradit Chinese Med Target & New Drug R, Yiwu 322000, Zhejiang, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, Chinese Acad Sci Key Lab Receptor Res, Shanghai 201203, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
7.Hubei Univ Arts & Sci, Xiangyang 441053, Peoples R China
8.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Xiaolong,Qi, Li-Feng-Rong,Wu, Yufeng,et al. Diverse C-H Activation in Asymmetric Multicomponent Coupling: Unlocking Anti-Parkinson Pseudo-Natural Macrocycles[J]. ACS CATALYSIS,2025:11.
APA Ma, Xiaolong.,Qi, Li-Feng-Rong.,Wu, Yufeng.,Liu, Shuai.,Liu, Xiujuan.,...&Yang, Weibo.(2025).Diverse C-H Activation in Asymmetric Multicomponent Coupling: Unlocking Anti-Parkinson Pseudo-Natural Macrocycles.ACS CATALYSIS,11.
MLA Ma, Xiaolong,et al."Diverse C-H Activation in Asymmetric Multicomponent Coupling: Unlocking Anti-Parkinson Pseudo-Natural Macrocycles".ACS CATALYSIS (2025):11.

入库方式： OAI收割

来源：上海药物研究所

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