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Metabolite differences between stems and leaves of Sarcandrae herba: A basis for rational medicinal part selection

文献类型：期刊论文

作者Xu, Yan-bo1,2; Gan, Wen-jing1,2; Liu, Xiao-kang2; Wang, Jia-wei2; Huang, Fei2; Li, Zhen-wei2; Zhang, Dai-di2; Guo, De-an1,2,3
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
出版日期2026-03-15
卷号270页码:12
关键词Sarcandrae herba Chemical constituents UPLC-Q-TOF-MS/MS Metabolomics Stem-leaf chemical differences
ISSN号0731-7085
DOI10.1016/j.jpba.2025.117279
通讯作者Guo, De-an(daguo@shutcm.edu.cn)
英文摘要The 2025 edition of the Chinese Pharmacopoeia designates the dried whole plant of Sarcandrae herba as the medicinal part; however, the frequent phenomenon of leaf detachment in practice raises concerns about its impact on the quality of the medicinal material. To address this, the present study systematically characterized the chemical basis of Sarcandrae herba using UPLC-Q-TOF-MS/MS technology. Combined with metabolomic approaches, we conducted chemical analyses on the stems and leaves of 30 batches of samples to identify and analyze differential metabolites and their distribution patterns. Additionally, the contents of two key marker components with significant differences in the whole plant, pure stems, and pure leaves were determined. The results demonstrated that a total of 103 chemical constituents were identified in the stems and leaves of Sarcandrae herba, encompassing organic acids, flavonoids, sesquiterpenoids, and coumarins, among which 24 were identified as significantly differential metabolites. Notably, isofraxidin exhibited specific enrichment in the stems, with its content in 15 batches of stems being five times higher than that in the leaves. Conversely, phenolic acids such as rosmarinic acid, chlorogenic acid, and neochlorogenic acid were predominantly distributed in the leaves, with the leaf content of rosmarinic acid being twice that of the stems. These findings reveal the characteristic distribution patterns of constituents in the stems and leaves of Sarcandrae herba, clarifying that leaf detachment may lead to the loss of bioactive phenolic acids and a relative increase in the proportion of isofraxidin, posing a quality risk for the medicinal material. This study provides a chemical foundation for understanding the scientific connotation of " whole plant for medicinal use" and offers important evidence for optimizing the quality control strategy of Sarcandrae herba medicinal materials.
资助项目Sanming Project of Medicine in Shenz-hen[SZZYSM202106004] ; Qi-Huang Chief Scientist Program of National Administration of Traditional Chinese Medicine
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001631040600002
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/322154]  
专题中国科学院上海药物研究所
通讯作者Guo, De-an
作者单位1.Guangdong Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Guangzhou 510006, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Yan-bo,Gan, Wen-jing,Liu, Xiao-kang,et al. Metabolite differences between stems and leaves of Sarcandrae herba: A basis for rational medicinal part selection[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2026,270:12.
APA Xu, Yan-bo.,Gan, Wen-jing.,Liu, Xiao-kang.,Wang, Jia-wei.,Huang, Fei.,...&Guo, De-an.(2026).Metabolite differences between stems and leaves of Sarcandrae herba: A basis for rational medicinal part selection.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,270,12.
MLA Xu, Yan-bo,et al."Metabolite differences between stems and leaves of Sarcandrae herba: A basis for rational medicinal part selection".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 270(2026):12.

入库方式： OAI收割

来源：上海药物研究所

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