Co-MHAT-Catalyzed Wacker-Type Oxidation of 1,3-Enynes into Ynones
文献类型：期刊论文
| 作者 | Jiang, Ying2,3; Zhao, Wen-Chao2,3; Xiao, Kai2,3; Zhou, Yu1,2,3; Huang, Wei1,2,3; Zhou, Shengbin2,3; Zhang, Feng-Hua2,3 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2025-12-05 |
| 页码 | 6 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.5c04558 |
| 英文摘要 | The transformation of 1,3-enynes is one of the important methods for obtaining a variety of valuable organic molecules. In the past few decades, significant progress has been made in the difunctionalization of 1,3-enynes via a radical process. However, the hydrofunctionalization of 1,3-enynes has been studied less. Herein, we describe the first example of reductive Co-MHAT-catalyzed Wacker-type oxidation of 1,3-enynes under air conditions with Markovnikov regioselectivity. Valuable conjugated ynones were obtained from the readily available starting material. Furthermore, a broad substrate scope with good functional group compatibility, simple operation, mild conditions, diverse downstream transformations, and excellent late-stage modifications demonstrated this method has significant advantages in practical utility. |
| WOS关键词 | MOLECULAR-OXYGEN ; REDUCTION HYDRATION ; OLEFINS ; ALKENES ; ALCOHOLS ; HYDROFUNCTIONALIZATION ; HYDROHYDRAZINATION ; HYDROALKOXYLATION ; RADICALS ; AZIDES |
| 资助项目 | Natural Science Foundation of Zhejiang Province[LQ24B020006] ; National Natural Science Foundation of China[22401060] ; National Key Research and Development Program of China[2023YFD1800100] ; University of Chinese Academy of Sciences[2023HIAS-V006] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001632001400001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322169]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Zhou, Shengbin; Zhang, Feng-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Key Lab Glycodrug Res Zhejiang Prov, Hangzhou 310024, Peoples R China 3.Univ Chinese Acad Sci, Beijing 101408, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Ying,Zhao, Wen-Chao,Xiao, Kai,et al. Co-MHAT-Catalyzed Wacker-Type Oxidation of 1,3-Enynes into Ynones[J]. ORGANIC LETTERS,2025:6. |
| APA | Jiang, Ying.,Zhao, Wen-Chao.,Xiao, Kai.,Zhou, Yu.,Huang, Wei.,...&Zhang, Feng-Hua.(2025).Co-MHAT-Catalyzed Wacker-Type Oxidation of 1,3-Enynes into Ynones.ORGANIC LETTERS,6. |
| MLA | Jiang, Ying,et al."Co-MHAT-Catalyzed Wacker-Type Oxidation of 1,3-Enynes into Ynones".ORGANIC LETTERS (2025):6. |
入库方式： OAI收割
来源：上海药物研究所
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