Contribution of Gli1+Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury
文献类型：期刊论文
| 作者 | Wang, Haixiao1,8,9; Huang, Xiuzhen7; Mou, Jialing7; Wang, Enci6; Li, Yan4,5; Pu, Wenjuan7; Xie, Yao3; Guo, Xiaoling2; Wang, Lixing6; Chu, Maoping1,8,9 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2025-12-03 |
| 页码 | 18 |
| 关键词 | atherosclerosis fate-mapping lineage tracing stem cell vascular smooth muscle cell |
| DOI | 10.1002/advs.202512897 |
| 通讯作者 | Zhou, Bin(zhoubin@sibs.ac.cn) ; Niu, Chao(niu_c@wmu.edu.cn) |
| 英文摘要 | Adventitial stem cells (ASCs), identified by Gli1 expression, have been proposed as key contributors to the vascular smooth muscle cell (SMC) population during atherosclerosis development. However, their precise role remains a subject of debate. To clarify this, a Gli1-CreER lineage tracing tool to track these cells in an atherosclerosis model is initially used. This fate-mapping studies revealed that Gli1+ cells contribute to a small subset of SMCs. To definitively differentiate between the true lineage transformation and potential ectopic labeling by Gli1-CreER in SMCs, a dual recombinase-mediated genetic strategy to label Gli1+ ASCs while eliminating ectopic labeling in SMCs is developed. The results from this dual lineage tracing approach demonstrated that Gli1+ ASCs do not contribute to the SMC population in atherosclerotic plaques. Instead, Gli1+ ASCs differentiate into a significant portion of SMCs after vascular anastomosis injury, suggesting their role is context-dependent. These findings challenge current paradigms and highlight the need to reconsider cellular targets for therapeutic interventions in atherosclerosis. |
| WOS关键词 | ADVENTITIAL FIBROBLASTS ; PROGENITOR CELLS ; VEIN GRAFTS ; CALCIFICATION ; MICE ; METALLOPROTEINASES ; INFLAMMATION ; MECHANISMS ; POPULATION ; APOPTOSIS |
| 资助项目 | Shenzhen Medical Research Fund[C2504001] ; Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China[LHDMY23H070001] ; National Science Foundation of China[82088101] ; National Science Foundation of China[32370783] ; National Science Foundation of China[32170848] ; National Science Foundation of China[32370897] ; National Science Foundation of China[82400561] ; National Science Foundation of China[32370802] ; National Science Foundation of China[82270441] ; Youth Innovation Promotion Association CAS, Shanghai Pilot Program for Basic Research - CAS, Shanghai Branch[JCYJ-SHFY-2021-0] ; China Postdoctoral Science Foundation[GZB20230534] ; China Postdoctoral Science Foundation[2023TQ0246] ; Pioneer and Leading Goose R&D Program of Zhejiang[2023C03030] ; CAS Project for Young Scientists in Basic Research[YSBR-012] ; National Key Research & Development Program of China[2024YFA1803302] ; National Key Research & Development Program of China[2023YFA1800700] ; National Key Research & Development Program of China[2022YFA1104200] ; National Key Research & Development Program of China[2023YFA1801300] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001629439200001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322181]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhou, Bin; Niu, Chao |
| 作者单位 | 1.Zhejiang Prov Clin Res Ctr Pediat Dis, Wenzhou 325000, Peoples R China 2.Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Sci Res Dept, Wenzhou 325000, Peoples R China 3.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Cardiol, Hangzhou 310009, Zhejiang, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264199, Shandong, Peoples R China 6.Fudan Univ, Dept Vasc Surg, Zhongshan Hosp, Shanghai 200031, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci,Key Lab Multicell Syst, Univ Chinese Acad Sci,New Cornerstone Sci Lab, Shanghai 200031, Peoples R China 8.Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Pediat Res Inst, Pediat Discipline Grp, Wenzhou 325000, Peoples R China 9.Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Childrens Heart Ctr, Wenzhou 325000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Haixiao,Huang, Xiuzhen,Mou, Jialing,et al. Contribution of Gli1+Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury[J]. ADVANCED SCIENCE,2025:18. |
| APA | Wang, Haixiao.,Huang, Xiuzhen.,Mou, Jialing.,Wang, Enci.,Li, Yan.,...&Niu, Chao.(2025).Contribution of Gli1+Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury.ADVANCED SCIENCE,18. |
| MLA | Wang, Haixiao,et al."Contribution of Gli1+Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury".ADVANCED SCIENCE (2025):18. |
入库方式： OAI收割
来源：上海药物研究所
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