Spatial matching between lobar leision severity and inhaled drug distribution: Pulmonary-targeted delivery of β-methyldigoxin against acute lung injury
文献类型：期刊论文
| 作者 | Nie, Qin1,5; Wang, Caifen1,5; Xiong, Ting1,5; Cao, Zeying1,2; Bao, Haojie1,5; Xu, Huipeng1; Zheng, Shiyu1; Wu, Li1; Yang, Rui3; Wang, Wei4 |
| 刊名 | POWDER TECHNOLOGY
 |
| 出版日期 | 2026-02-28 |
| 卷号 | 469页码:11 |
| 关键词 | Inhalable dry powder Pulmonary delivery Acute lung injury Spatial matching Targeted therapy |
| ISSN号 | 0032-5910 |
| DOI | 10.1016/j.powtec.2025.121928 |
| 通讯作者 | Wang, Wei(13302055566@126.com) ; Zhang, Jiwen(jwzhang@simm.ac.cn) ; Sun, Lixin(slx04@163.com) |
| 英文摘要 | Acute lung injury (ALI) is a highly prevalent and life-threatening respiratory disease, and inhalable dry powder (IDP) remains the promising approach for delivering therapeutics to the lungs to treat this condition. However, a major limitation of the clinical research lay in achieving targeted therapy that accounted for lung lobes distribution. In this study, the beta-methyldigoxin (beta-MD) inhalable dry powder (IDP) obtained by jet milling displayed excellent pulmonary deposition behaviors in vitro with a fine particle fraction (FPF) of 79.60 +/- 4.89%. After pulmonary delivery of beta-MD IDP in rats, the spatial distribution levels of beta-MD were determined by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) in each lobe, which revealed that the lung right lower lobe (RLL) had the highest drug concentration, with its area under the curve (AUC) representing 38.34% of the total lung exposure. Meanwhile, the lipopolysaccharide (LPS)-induced ALI model was successfully established through direct intratracheal instillation of LPS in rats, with the highest inflammatory level recorded using qPCR technology in the RLL. Furthermore, the inhaled beta-MD IDP effectively reduced the release of pro-inflammatory factors in the RLL, and significantly alleviated the symptoms of ALI (p < 0.001). This study revealed the spatial matching between the tissue lesion burden in ALI and the distributions of inhaled beta-MD IDP in the lobes, which held substantial clinical promise for the inhalational targeted treatment of ALI. |
| WOS关键词 | CARDIAC-GLYCOSIDES ; NA+/K+-ATPASE ; DEPOSITION |
| 资助项目 | National Natural Science Founda-tion of China[82273863] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001629756800004 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322190]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Wei; Zhang, Jiwen; Sun, Lixin |
| 作者单位 | 1.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, 2 Tiantan Xili, Beijing 100050, Peoples R China 4.Medifarma Tianjin Biotechnol Co Ltd, 6 Hitech Huake 8th Rd, Tianjin 300392, Peoples R China 5.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, 103 Wenhua Rd, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nie, Qin,Wang, Caifen,Xiong, Ting,et al. Spatial matching between lobar leision severity and inhaled drug distribution: Pulmonary-targeted delivery of β-methyldigoxin against acute lung injury[J]. POWDER TECHNOLOGY,2026,469:11. |
| APA | Nie, Qin.,Wang, Caifen.,Xiong, Ting.,Cao, Zeying.,Bao, Haojie.,...&Sun, Lixin.(2026).Spatial matching between lobar leision severity and inhaled drug distribution: Pulmonary-targeted delivery of β-methyldigoxin against acute lung injury.POWDER TECHNOLOGY,469,11. |
| MLA | Nie, Qin,et al."Spatial matching between lobar leision severity and inhaled drug distribution: Pulmonary-targeted delivery of β-methyldigoxin against acute lung injury".POWDER TECHNOLOGY 469(2026):11. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。