Dimeric alkenyl α-pyrones from Cryptocarya calcicola with their cytotoxicity
文献类型：期刊论文
| 作者 | Liu, Yu2; Li, Wei3; Su, Yu2; Rao, Li2; He, Qian2; You, Yun-Xia2; Zhang, Chuan-Rui1,2,3,4 |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2026-03-01 |
| 卷号 | 243页码:7 |
| 关键词 | Cryptocarya calcicola Lauraceae alpha-pyrone dimers X-ray crystallography Biosynthetic pathway proposal Cytotoxicity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2025.114724 |
| 通讯作者 | Zhang, Chuan-Rui(zhangchuanrui@simm.ac.cn) |
| 英文摘要 | The genus Cryptocarya is renowned for producing characteristic content of alkyl or alkenyl alpha-pyrones with intriguing stereochemical complexity and diverse pharmacological properties. In this study, four unprecedented dimeric alkenyl alpha-pyrones featuring an unusual pentacyclo[8.4.2.02,9.05,8.011,14]hexadecane core scaffold, named crypcalcones A-D (1-4), were isolated from Cryptocarya calcicola, an unexplored endemic Chinese species. Their structures were established through a combination of extensive NMR spectroscopic analysis, single-crystal X-ray crystallography, and electronic circular dichroism (ECD) spectroscopy. This is the first report of alpha-pyrone dimers from the genus Cryptocarya, expanding the known structural diversity of alpha-pyrones. Compounds 1-4 are proposed to arise from an initial 8 pi-6 pi e electrocyclization of a polyene alpha-pyrone precursor, followed by an intramolecular [4 + 2] cycloaddition. Notably, these compounds demonstrated selective cytotoxicity against HCT-116 colorectal cancer cells, with IC50 values ranging from 2.02 to 7.00 mu M. |
| WOS关键词 | INHIBITORY-ACTIVITY ; FLAVONOIDS ; COMPOUND |
| 资助项目 | National Natural Science Foundation of China[22177016] ; Fund of State Key Laboratory of Phyto-chemistry and Plant Resources in West China[P2020-KF09] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001632470900001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322345]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Chuan-Rui |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources Wes, Kunming 650201, Peoples R China 2.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yu,Li, Wei,Su, Yu,et al. Dimeric alkenyl α-pyrones from Cryptocarya calcicola with their cytotoxicity[J]. PHYTOCHEMISTRY,2026,243:7. |
| APA | Liu, Yu.,Li, Wei.,Su, Yu.,Rao, Li.,He, Qian.,...&Zhang, Chuan-Rui.(2026).Dimeric alkenyl α-pyrones from Cryptocarya calcicola with their cytotoxicity.PHYTOCHEMISTRY,243,7. |
| MLA | Liu, Yu,et al."Dimeric alkenyl α-pyrones from Cryptocarya calcicola with their cytotoxicity".PHYTOCHEMISTRY 243(2026):7. |
入库方式： OAI收割
来源：上海药物研究所
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