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Tetrahydrofuran-and dihydrofuran-containing nor-clerodane diterpenoids from Teucrium viscidum: Isolation, stereochemical assignment, and anti-hepatic fibrosis activity

文献类型：期刊论文

作者Hu, Xin-Yi1,2,3; Gan, Lu6; Zhang, Fei-Yu2; Zhu, Guang-Hai2; Liao, Yi-Ling6; Huang, Guo-Sen4,5; Guo, De-an1,2,3; Li, Wei1,2,3
刊名PHYTOCHEMISTRY
出版日期2026-03-01
卷号243页码:11
关键词Teucrium viscidum Lamiaceae Nor -clerodane diterpenoid Anti-hepatic fibrosis activity
ISSN号0031-9422
DOI10.1016/j.phytochem.2025.114723
通讯作者Huang, Guo-Sen(zsszyyflk@163.com) ; Guo, De-an(daguo@simm.ac.cn) ; Li, Wei(liwei1@simm.ac.cn)
英文摘要Ten previously undescribed nor-clerodane diterpenoids, teuvinoids A-J (1-10), were isolated from the whole plants of Teucrium viscidum. Comprehensive structural elucidation, including unambiguous determination of absolute configurations, was accomplished using spectroscopic analysis, electronic circular dichroism, and single-crystal X-ray diffraction. Teuvinoids A (1) and B (2) are particularly noteworthy for featuring an unusual 2,3,4,5-tetrahydroxylated tetrahydrofuran moiety. Compounds 1 and 2 exhibited anti-hepatic fibrosis effects in TGF-beta 1-induced LX-2 hepatic stellate cells, as demonstrated by downregulation of key fibrotic biomarkers including fibronectin, collagen I, and alpha-smooth muscle actin.
资助项目China Postdoctoral Science Foundation[2025M773526] ; Natural Science Foundation of Guangdong Province[2025A1515011199] ; National Demonstration Pilot Project for the Inheritance and Innovative Development of Traditional Chinese Medicine-Research Project on Traditional Chinese Medicine at Zhongshan Hospital of Traditional Chinese Medicine[YN2024A010]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:001630576100001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/322357]  
专题中国科学院上海药物研究所
通讯作者Huang, Guo-Sen; Guo, De-an; Li, Wei
作者单位1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Zhongshan Hosp Tradit Chinese Med, Dept Radiotherapy, Zhongshan 528400, Peoples R China
5.Guangzhou Univ Tradit Chinese Med, Clin Med Coll 10, Dept Radiotherapy, Zhongshan 528400, Peoples R China
6.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Xin-Yi,Gan, Lu,Zhang, Fei-Yu,et al. Tetrahydrofuran-and dihydrofuran-containing nor-clerodane diterpenoids from Teucrium viscidum: Isolation, stereochemical assignment, and anti-hepatic fibrosis activity[J]. PHYTOCHEMISTRY,2026,243:11.
APA Hu, Xin-Yi.,Gan, Lu.,Zhang, Fei-Yu.,Zhu, Guang-Hai.,Liao, Yi-Ling.,...&Li, Wei.(2026).Tetrahydrofuran-and dihydrofuran-containing nor-clerodane diterpenoids from Teucrium viscidum: Isolation, stereochemical assignment, and anti-hepatic fibrosis activity.PHYTOCHEMISTRY,243,11.
MLA Hu, Xin-Yi,et al."Tetrahydrofuran-and dihydrofuran-containing nor-clerodane diterpenoids from Teucrium viscidum: Isolation, stereochemical assignment, and anti-hepatic fibrosis activity".PHYTOCHEMISTRY 243(2026):11.

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来源：上海药物研究所

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