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Identification of lymphangiogenesis-related diagnostic model for predicting abdominal aortic aneurysm onset and progression and validation of lymphopoiesis in abdominal aortic aneurysm

文献类型：期刊论文

作者Qin, Su1,3; Zhang, Jing2; Cao, Meifang2,3; Jiang, Tao3,4; Jiang, Baohong1,2,3
刊名MOLECULAR AND CELLULAR PROBES
出版日期2026-02-01
卷号85页码:16
关键词Abdominal aortic aneurysm Bioinformatics Diagnostic biomarkers Lymphangiogenesis Lymphatic drainage obstruction
ISSN号0890-8508
DOI10.1016/j.mcp.2025.102054
通讯作者Jiang, Baohong(jiangbh@simm.ac.cn)
英文摘要This study aims to explore the lymphangiogenesis (LG)-related diagnostic markers of abdominal aortic aneurysm (AAA) through bioinformatics, as well as the alteration of the regional lymphatic system during the progression of AAA and the influence of lymphatic drainage obstruction on AAA progression. 2957 differentially expressed genes (DEGs) were identified between the AAA patient group and the healthy donor group in Gene Expression Omnibus microarray datasets. Subsequently, the DEGs and the LG gene were intersected, and 93 genes were obtained. Weighted gene co-expression network analysis (WGCNA) was performed to obtain module genes. Module genes intersected with the above 93 genes, and 26 genes were obtained. Five hub genes (HSPA5, RAB10, RAB1A, RAF1, SMAD4) identified by machine learning may serve as diagnostic candidates for AAA patients through nomogram and ROC evaluation. Gene set enrichment analysis (GSEA) and immune infiltration analysis were performed further to understand the function of these candidate genes and explore the effect of immunity in AAA, respectively. By establishing an AAA animal model, it was found that the iliac lymph nodes around the abdominal aorta were significantly enlarged, and the number and lumen size of lymphatic vessels in the vessel wall were both significantly increased during the progression of AAA. Additionally, AAA was significantly promoted by ligating lymphatic vessels, which caused lymphatic drainage obstruction around the abdominal aorta. Our findings have the potential to enhance knowledge about the development and diagnosis of AAA.
WOS关键词CANCER ; TRANSCRIPTION ; ENVIRONMENT ; INJURY ; GENES
资助项目National Natural Science Foundation of China[82270501]
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Cell Biology
语种英语
WOS记录号WOS:001636522000001
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/322360]  
专题中国科学院上海药物研究所
通讯作者Jiang, Baohong
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200120, Peoples R China
4.China Pharmaceut Univ, Nanjing 211198, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Qin, Su,Zhang, Jing,Cao, Meifang,et al. Identification of lymphangiogenesis-related diagnostic model for predicting abdominal aortic aneurysm onset and progression and validation of lymphopoiesis in abdominal aortic aneurysm[J]. MOLECULAR AND CELLULAR PROBES,2026,85:16.
APA Qin, Su,Zhang, Jing,Cao, Meifang,Jiang, Tao,&Jiang, Baohong.(2026).Identification of lymphangiogenesis-related diagnostic model for predicting abdominal aortic aneurysm onset and progression and validation of lymphopoiesis in abdominal aortic aneurysm.MOLECULAR AND CELLULAR PROBES,85,16.
MLA Qin, Su,et al."Identification of lymphangiogenesis-related diagnostic model for predicting abdominal aortic aneurysm onset and progression and validation of lymphopoiesis in abdominal aortic aneurysm".MOLECULAR AND CELLULAR PROBES 85(2026):16.

入库方式： OAI收割

来源：上海药物研究所

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