Proton-Activated Chloride Channel Modulates Motor Function after Acute Spinal Cord Injury
文献类型：期刊论文
| 作者 | Wu, Jianwei1; Xiao, Wenbiao1; Lu, Zian1; Huang, Han1; Xu, Haocheng1; Chen, Zhenhao1; Wang, Hongli1; Feng, Jing2 |
| 刊名 | ACS CHEMICAL NEUROSCIENCE
 |
| 出版日期 | 2025-12-15 |
| 页码 | 15 |
| 关键词 | spinal cord injury PAC channel microglia oxidative stress |
| ISSN号 | 1948-7193 |
| DOI | 10.1021/acschemneuro.5c00855 |
| 通讯作者 | Chen, Zhenhao(chenzhenhao17@126.com) ; Wang, Hongli(wanghongli0212@163.com) ; Feng, Jing(fengjing@simm.ac.cn) |
| 英文摘要 | Spinal cord injury (SCI) disrupts motor, sensory, and autonomic functions, profoundly impairing quality of life. Here, we investigate the role of the proton-activated chloride (PAC) channel, encoded by Pacc1, in motor function recovery following SCI. We found that PAC is expressed in the spinal cord, predominantly in microglia, and its expression markedly increases after injury. In Pacc1 knockout mice, motor recovery was significantly improved, accompanied by reduced microgliosis. Moreover, microglia-specific deletion of Pacc1 decreased lesion volume and further enhanced motor recovery, as demonstrated by behavioral assessments. Mechanistically, loss of Pacc1 in microglia suppressed excessive microglial activation and the release of pro-inflammatory cytokines after injury. Together, these findings identify the PAC channel as an injury-induced regulator that aggravates inflammation and impairs motor recovery. Targeting PAC may thus represent a promising therapeutic strategy to mitigate inflammation and promote spinal cord repair after SCI. |
| WOS关键词 | RECTIFYING ANION CHANNELS ; INDUCED CELL-DEATH ; HV1 ; MICROGLIA ; RECOVERY ; IMMUNE ; RATS ; PAC ; PH |
| 资助项目 | Chinese Academy of Sciences[XDB1060000] ; Natural Science Foundation of Shanghai Municipality[23ZR1474500] ; National Natural Science Foundation of China[32241003] ; State Key Laboratory of Chemical Biology[SKLCB-2025-02] ; National Key Research and Development Program of China[2024YFC3505305] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001640441300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322363]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Zhenhao; Wang, Hongli; Feng, Jing |
| 作者单位 | 1.Fudan Univ, Huashan Hosp, Dept Orthopaed, Shanghai 200040, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Jianwei,Xiao, Wenbiao,Lu, Zian,et al. Proton-Activated Chloride Channel Modulates Motor Function after Acute Spinal Cord Injury[J]. ACS CHEMICAL NEUROSCIENCE,2025:15. |
| APA | Wu, Jianwei.,Xiao, Wenbiao.,Lu, Zian.,Huang, Han.,Xu, Haocheng.,...&Feng, Jing.(2025).Proton-Activated Chloride Channel Modulates Motor Function after Acute Spinal Cord Injury.ACS CHEMICAL NEUROSCIENCE,15. |
| MLA | Wu, Jianwei,et al."Proton-Activated Chloride Channel Modulates Motor Function after Acute Spinal Cord Injury".ACS CHEMICAL NEUROSCIENCE (2025):15. |
入库方式： OAI收割
来源：上海药物研究所
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