An H2O2 activated Ag2S:In-Cu nanoprobe for in vitro synergistic tumor treatment
文献类型：期刊论文
| 作者 | Zhang, Xiaoyan1; Liu, Ruiqi2; Yu, Zhouyu1; Chang, Baisong1 |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2025-12-09 |
| 页码 | 13 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/d5nr04196a |
| 英文摘要 | Ag2S nanoparticles exhibit tremendous application potential in biomedical fields such as photothermal therapy (PTT) and photoacoustic imaging. However, they have certain drawbacks, including relatively weak near-infrared (NIR) absorption capacity and rather limited photothermal conversion efficiency. In this study, we designed an NIR-II fluorescent probe that can be activated by the tumor microenvironment (TME). Specifically, we first incorporated In3+ into Ag2S nanoparticles, then allowed Cu2+ to complex with them, and finally encapsulated the resulting complexes with polyethylene glycol (PEG) (denoted as ACP). The incorporation of In3+ effectively mitigated the lattice defects of Ag2S, significantly enhancing its NIR absorption capacity and thereby strengthening the therapeutic effect of PTT. Under 808 nm photoexcitation, the reaction of ACP nanoparticles with H2O2 exhibited a photothermal conversion efficiency of up to 67.8%. The introduced Cu2+ can react with the excessive H2O2 in tumor cells to generate highly oxidizing hydroxyl radicals ((OH)-O-center dot), enabling efficient chemodynamic therapy (CDT). Moreover, this process also depleted glutathione (GSH) within tumor cells, further disrupting the antioxidant defense system of tumor cells and greatly enhancing the therapeutic efficacy of CDT. This study offers a novel approach for utilizing responsive nanoparticles to enhance the dual synergistic in vitro effects of PTT/CDT. |
| 资助项目 | National Natural Science Foundation of China[52373307] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001639448200001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322378]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Chang, Baisong |
| 作者单位 | 1.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaoyan,Liu, Ruiqi,Yu, Zhouyu,et al. An H2O2 activated Ag2S:In-Cu nanoprobe for in vitro synergistic tumor treatment[J]. NANOSCALE,2025:13. |
| APA | Zhang, Xiaoyan,Liu, Ruiqi,Yu, Zhouyu,&Chang, Baisong.(2025).An H2O2 activated Ag2S:In-Cu nanoprobe for in vitro synergistic tumor treatment.NANOSCALE,13. |
| MLA | Zhang, Xiaoyan,et al."An H2O2 activated Ag2S:In-Cu nanoprobe for in vitro synergistic tumor treatment".NANOSCALE (2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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