Rh(III)-Catalyzed (Benz)imidazole-Directed [4+2] Cyclization of Indoles With Maleimides: Facile Access to C6-Fused Indole Polyheterocyclic Compounds
文献类型：期刊论文
| 作者 | Wang, Qiang3,4; Khan, Maaz2,3,5; Chen, Shuangyuan3; Wu, Qingqing3; Zhao, Guilong1,2,3,4,5; Jadhav, Pankaj3,5 |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2025-12-12 |
| 页码 | 8 |
| 关键词 | (benz)imidazole C6 [4+2] cyclization directing group indole maleimide |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.202500924 |
| 通讯作者 | Zhao, Guilong(zhao_guilong@126.com) ; Jadhav, Pankaj(pankaj0487@zidd.ac.cn) |
| 英文摘要 | We report the first rhodium (III)-catalyzed, (benz)imidazole-directed site- selective [4+2] cyclization of indoles with maleimides, enabling the efficient synthesis of C6-fused polyheterocyclic indoles. This strategy features with wide substrate scope and excellent functional group tolerance. Mechanistic insights were gained through control experiments, deuterium-labeling, and competitive studies. Application of this methodology produced novel heterocycles via simple postsynthetic chemical transformations, showcasing the synthetic utility of this approach. |
| WOS关键词 | ANTIPROLIFERATIVE ACTIVITY ; TELEOCIDIN-B ; ACTIVATION ; ANNULATION ; DESIGN |
| 资助项目 | Creative Research Group of Zhongshan City[CXTD2022011] ; Basic and Applied Basic Research Foundation of Guangdong Province[2023A1515012259] ; National Natural Science Foundation of China[82441046] ; Zhongshan Municipal Natural Science Foundation[2023B2019] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001636942300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322384]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhao, Guilong; Jadhav, Pankaj |
| 作者单位 | 1.Guizhou Med Univ, Coll Pharm, Guiyang, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 4.Dalian Univ Technol, Sch Chem Engn Ocean & Life Sci, Dept life & Pharmaceut Sci, Panjin, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qiang,Khan, Maaz,Chen, Shuangyuan,et al. Rh(III)-Catalyzed (Benz)imidazole-Directed [4+2] Cyclization of Indoles With Maleimides: Facile Access to C6-Fused Indole Polyheterocyclic Compounds[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2025:8. |
| APA | Wang, Qiang,Khan, Maaz,Chen, Shuangyuan,Wu, Qingqing,Zhao, Guilong,&Jadhav, Pankaj.(2025).Rh(III)-Catalyzed (Benz)imidazole-Directed [4+2] Cyclization of Indoles With Maleimides: Facile Access to C6-Fused Indole Polyheterocyclic Compounds.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,8. |
| MLA | Wang, Qiang,et al."Rh(III)-Catalyzed (Benz)imidazole-Directed [4+2] Cyclization of Indoles With Maleimides: Facile Access to C6-Fused Indole Polyheterocyclic Compounds".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2025):8. |
入库方式： OAI收割
来源：上海药物研究所
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