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Cu-Catalyzed Highly Selective Ritter-Type Reaction of Enaminonitriles with Cycloketoxime Esters: A Direct Route to Diverse α-Tertiary Amines

文献类型：期刊论文

作者Sajjad, Farrukh4; Zhao, Jiaqi3,5; Zheng, Ling1; Zhao, Yanling2; Jin, Xiaomeng3,5; Zhu, Guangli3,5; Liu, Hanfu4; Zheng, Xinni4; Lu, Cheng6; Chen, Tie-Gen3,4,5
刊名ORGANIC LETTERS
出版日期2025-12-16
页码6
ISSN号1523-7060
DOI10.1021/acs.orglett.5c04580
通讯作者Lu, Cheng(luchengjy@ust.hk) ; Chen, Tie-Gen(chentiegen@simm.ac.cn)
英文摘要Significant progress has been made in recent years in Ritter-type reactions, particularly in developing diverse pathways for carbocation generation. However, most existing methods rely on stoichiometric oxidants or expensive reagents and are limited in nitrile scope. Herein, we report a highly selective Ritter-type reaction between enaminonitriles and oxime esters. This method provides efficient access to diversely functionalized, sterically congested alpha-tertiary amines (ATAs) under mild conditions with excellent selectivity, addressing key limitations of previous approaches.
WOS关键词H AMINATION ; CHEMOSELECTIVITY ; INDOLES
资助项目Chinese Academy of Sciences[NA] ; Science and Technology Commission of Shanghai Municipality[23ZR1474300] ; National Natural Science Foundation of China[22371303] ; Shanghai Rising-Star Program[21QA1411000] ; Zhongshan Science and Technology Bureau[2021B2014]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001640400400001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/322387]  
专题中国科学院上海药物研究所
通讯作者Lu, Cheng; Chen, Tie-Gen
作者单位1.Zunyi Med Univ, Zhuhai 519090, Peoples R China
2.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 561113, Guizhou, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong 999077, Peoples R China
推荐引用方式
GB/T 7714		 Sajjad, Farrukh,Zhao, Jiaqi,Zheng, Ling,et al. Cu-Catalyzed Highly Selective Ritter-Type Reaction of Enaminonitriles with Cycloketoxime Esters: A Direct Route to Diverse α-Tertiary Amines[J]. ORGANIC LETTERS,2025:6.
APA Sajjad, Farrukh.,Zhao, Jiaqi.,Zheng, Ling.,Zhao, Yanling.,Jin, Xiaomeng.,...&Chen, Tie-Gen.(2025).Cu-Catalyzed Highly Selective Ritter-Type Reaction of Enaminonitriles with Cycloketoxime Esters: A Direct Route to Diverse α-Tertiary Amines.ORGANIC LETTERS,6.
MLA Sajjad, Farrukh,et al."Cu-Catalyzed Highly Selective Ritter-Type Reaction of Enaminonitriles with Cycloketoxime Esters: A Direct Route to Diverse α-Tertiary Amines".ORGANIC LETTERS (2025):6.

入库方式： OAI收割

来源：上海药物研究所

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