Biomimetic direct hydroperoxidation of unactivated C(sp3)-H bonds enables effective functionalization of diverse types of natural products and/or drugs
文献类型：期刊论文
| 作者 | Zheng, Cheng-Yu2; Xi, Rui1,2; Yue, Jian-Min1,2 |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2025-12-10 |
| 页码 | 7 |
| 关键词 | organic hydroperoxides photocatalysis H atom transfer green oxidation late-stage functionalization |
| ISSN号 | 1674-7291 |
| DOI | 10.1007/s11426-025-3028-6 |
| 英文摘要 | Organic hydroperoxides are a class of biologically significant molecules that exist ubiquitously in nature. The ideal synthesis is direct hydroperoxidation of C(sp3)-H bonds, which remained a substantial challenge, particularly for the unactivated C(sp3)-H bonds. Inspired by the bio-catalysis of cyclooxygenase, a direct and site-selective photochemical hydroperoxidation of unactivated C(sp3)-H bonds was thus developed involving O2 as the oxidant and bromine radical as the catalyst. This method, demonstrated by plenty of substrates (63 examples) enables the late-stage functionalization of diverse types of natural products and/or drugs, such as terpenoids, amino acids, peptides, sugars and phosphonates. |
| WOS关键词 | C-H BONDS ; SINGLET OXYGEN ; HYDROXYLATION ; OXIDATION ; ACID ; OXYFUNCTIONALIZATION ; ARTEMISININ ; ALKYLATION ; ALKANES ; SITE |
| 资助项目 | National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[22494691] ; National Natural Science Foundation of China[22507133] ; Postdoctoral Fellowship Program of China Postdoctoral Science Foundation (CPSF)[GZC20241826] ; Shanghai Post-doctoral Excellence Program[2023711] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001638781600001 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322396]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Cheng-Yu,Xi, Rui,Yue, Jian-Min. Biomimetic direct hydroperoxidation of unactivated C(sp3)-H bonds enables effective functionalization of diverse types of natural products and/or drugs[J]. SCIENCE CHINA-CHEMISTRY,2025:7. |
| APA | Zheng, Cheng-Yu,Xi, Rui,&Yue, Jian-Min.(2025).Biomimetic direct hydroperoxidation of unactivated C(sp3)-H bonds enables effective functionalization of diverse types of natural products and/or drugs.SCIENCE CHINA-CHEMISTRY,7. |
| MLA | Zheng, Cheng-Yu,et al."Biomimetic direct hydroperoxidation of unactivated C(sp3)-H bonds enables effective functionalization of diverse types of natural products and/or drugs".SCIENCE CHINA-CHEMISTRY (2025):7. |
入库方式： OAI收割
来源：上海药物研究所
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