NIR-II organic fluorophores integrated with blood-brain barrier-penetrating strategies for brain disease theranostics
文献类型：期刊论文
| 作者 | Wang, Xiaobo2,3; Tan, Yuying4; Yan, Jierui2; Chen, Min2; Xie, Na2; Wu, Sha2; Fan, Fuhan2; Qi, Luming2; Gu, Shuangxi4; Qian, Kun5 |
| 刊名 | COORDINATION CHEMISTRY REVIEWS
 |
| 出版日期 | 2026-03-15 |
| 卷号 | 551页码:29 |
| ISSN号 | 0010-8545 |
| DOI | 10.1016/j.ccr.2025.217466 |
| 英文摘要 | The precise diagnosis and effective treatment of brain diseases have long posed significant challenges in the field of neuroscience. In recent years, near-infrared II (NIR-II, 1000-1700 nm) fluorescence imaging has emerged as a revolutionary tool for high-resolution in vivo brain imaging, owing to its advantages such as deep tissue penetration and minimal autofluorescence. This review systematically summarizes recent advances in NIR-II organic fluorophores applied in the diagnosis and treatment of brain disorders, with particular emphasis on molecular design strategies and optimization of optical properties. Moreover, the key to achieving effective diagnosis and therapy lies in the fluorophores' ability to efficiently cross the blood-brain barrier (BBB). Therefore, this work explores various active targeting and stimulus-responsive delivery strategies developed to overcome the BBB. Furthermore, we highlight the applications of these functionalized NIR-II organic probes in brain disease imaging and therapeutic visualization. Finally, we discuss current challenges and future perspectives in this field, aiming to provide insights for advancing the application of NIR-II fluorophores in precision medicine for brain diseases. |
| WOS关键词 | PHOTOTHERMAL THERAPY ; DESIGN ; NANOPARTICLES ; CHROMOPHORES ; WINDOW ; DYES |
| 资助项目 | National Natural Science Foundation of China[82474185] ; National Natural Science Foundation of China[22307036] ; National Natural Science Foundation of China[U23A20520] ; Postdoctoral Fellowship Program of CPSF[GZB20250890] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB0830300] ; Young Elite Scientists Sponsorship Program by CACM[CACM-2024-QNRC2-B07] ; Science & Technology Department of Sichuan Province[2024NSFSC1845] ; Xinglin Scholar Research Promotion Project of Chengdu University of TCM[QJJJ2024027] ; Joint Innovation Fund of Health Commission of Chengdu and Chengdu University of Traditional Chinese Medicine[WXLH202403076] ; Joint Innovation Fund of Health Commission of Chengdu and Chengdu University of Traditional Chinese Medicine[WXLH202402008] ; Shandong Laboratory Program[SYS202205] ; China Scholarship Council (CSC)[202106270027] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001638555700001 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322402]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Meng, Xianli; Ding, Qihang; Hou, Ya; Cheng, Zhen; Li, Yang |
| 作者单位 | 1.Korea Univ, Dept Chem, Seoul 02841, South Korea 2.Chengdu Univ Tradit Chinese Med, Lab Innovat & Effect Uses Chinese Drug Germplasm R, Innovat Inst Chinese Med & Pharm, Sch Pharm,Inst Interdisciplinary Studies, Chengdu 611137, Sichuan, Peoples R China 3.Univ Tradit Chinese Med, TCM Integrated High Altitude Med Ctr, TCM Prevent & Treatment Metab & Chron Dis Key Lab, Inst High Altitude Multimorbid,Hosp Chengdu, Chengdu 610075, Peoples R China 4.Wuhan Inst Technol, Sch Chem Engn & Pharm, Key Lab Green Chem Proc, Minist Educ,Pharm Res Inst,Sch Chem, Wuhan 430205, Hubei, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaobo,Tan, Yuying,Yan, Jierui,et al. NIR-II organic fluorophores integrated with blood-brain barrier-penetrating strategies for brain disease theranostics[J]. COORDINATION CHEMISTRY REVIEWS,2026,551:29. |
| APA | Wang, Xiaobo.,Tan, Yuying.,Yan, Jierui.,Chen, Min.,Xie, Na.,...&Li, Yang.(2026).NIR-II organic fluorophores integrated with blood-brain barrier-penetrating strategies for brain disease theranostics.COORDINATION CHEMISTRY REVIEWS,551,29. |
| MLA | Wang, Xiaobo,et al."NIR-II organic fluorophores integrated with blood-brain barrier-penetrating strategies for brain disease theranostics".COORDINATION CHEMISTRY REVIEWS 551(2026):29. |
入库方式： OAI收割
来源：上海药物研究所
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