Biomimetic Total Synthesis of Dispirocochlearoids A-C and Related Ganoderma Meroterpenoid Dimers
文献类型：期刊论文
| 作者 | Shi, Sheng-Jie2; Liu, Xu-Liang2; Yang, Lin2; Zhan, De-Sheng2; Chen, Lin-Hai3; Yin, Jian-Peng2; Nan, Fa-Jun1,3 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2025-12-26 |
| 卷号 | 27期号:51页码:14181-14186 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.5c04234 |
| 英文摘要 | The first total synthesis of the anti-inflammatory Ganoderma meroterpenoid dimers dispirocochlearoids A-C, along with five of their diastereomers-potential unreported natural products-has been accomplished using a convergent strategy that leveraged common intermediates derived from dayaolingzhiol M. The synthesis features several key steps: a hetero-Diels-Alder reaction, a hydrolysis/double-bond migration cascade to assemble the D/E-bicyclic core, and a condensation/intramolecular aldol/lactonization cascade that constructs the final B/C-bicyclic system of dispirocochlearoids A-C. |
| WOS关键词 | INHIBITORS ; SKELETON ; POTENT ; PAIR |
| 资助项目 | Natural Science Foundation of Shandong Province[ZR2023QH355] ; Key Technology Research and Development Program of Shandong Province[2025CXPT012] ; National Key Research and Development Program of China[2023YFA0915800] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001638364800001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322408]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Yin, Jian-Peng; Nan, Fa-Jun |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Yantai Inst Pharmaceut Sci, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Sheng-Jie,Liu, Xu-Liang,Yang, Lin,et al. Biomimetic Total Synthesis of Dispirocochlearoids A-C and Related Ganoderma Meroterpenoid Dimers[J]. ORGANIC LETTERS,2025,27(51):14181-14186. |
| APA | Shi, Sheng-Jie.,Liu, Xu-Liang.,Yang, Lin.,Zhan, De-Sheng.,Chen, Lin-Hai.,...&Nan, Fa-Jun.(2025).Biomimetic Total Synthesis of Dispirocochlearoids A-C and Related Ganoderma Meroterpenoid Dimers.ORGANIC LETTERS,27(51),14181-14186. |
| MLA | Shi, Sheng-Jie,et al."Biomimetic Total Synthesis of Dispirocochlearoids A-C and Related Ganoderma Meroterpenoid Dimers".ORGANIC LETTERS 27.51(2025):14181-14186. |
入库方式： OAI收割
来源：上海药物研究所
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