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Standardization of nasal airway structure model of Chinese Han nationality for characterization of nasal formulation spatial deposition atlases

文献类型：期刊论文

作者Li, Zeru4,5; Xu, Huipeng4; Wang, Siwen1,4; Nie, Qin4; Jia, Bingqian1,4; Su, Jiawen4,6; Xu, Guanghong6; Yang, Rui2; Wang, Zhigang3; Zhang, Jiwen1,4,5
刊名ACTA PHARMACEUTICA SINICA B
出版日期2025-12-01
卷号15期号:12页码:6698-6713
关键词Chinese Han nationality Statistical shape model Standard nasal airway structure model Spatial deposition atlas Deposition fraction Nasal formulation Nasal spray Nasal powder
ISSN号2211-3835
DOI10.1016/j.apsb.2025.09.018
通讯作者Wang, Zhigang(wuli@simm.ac.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) ; Wu, Li(hmrywzg@sina.com)
英文摘要The deposition characteristics of nasal formulations directly determine the efficacy of the drugs, whilst the complexity of human nasal airway structure encumbers quantitative evaluation of nasal spatial deposition. Male and female standard nasal airway structure models were calculated from computed tomography data of 128 Chinese Han nationality using statistical shape model. The deposition evaluation devices were further designed, and an imaging method was then employed to obtain drug deposition information. Furthermore, drug spatial deposition atlases were proposed by UV unwrapping, a mathematical mapping procedure flattening three-dimensional (3D) information to two-dimension bidirectionally, to achieve quantification of drug deposition fractions in the regions of interest. Moreover, the feasibility and universality of this method were verified by correlating it with the chemical quantitative results and computational fluid dynamic simulation of drug deposition of mometasone furoate nasal spray and hydroxypropyl methylcellulose nasal powder, respectively. Finally, the unique drug spatial deposition atlases of these two formulations in the male and female evaluation devices were generated, respectively. In summary, the standard nasal airway structure models of the Chinese Han nationality and the drug spatial deposition atlases provide scientific tools for the formulation optimization and quality control of nasal formulations. (c) 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
WOS关键词SPRAY ; DELIVERY ; PATTERNS
资助项目National Natural Science Foun-dation of China[82273863]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001642080000001
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/322411]  
专题中国科学院上海药物研究所
通讯作者Wang, Zhigang; Zhang, Jiwen; Wu, Li
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
3.Nantong Haimen Peoples Hosp, Nantong 226199, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
6.Jiangsu Yungou Pharmaceut Technol Co Ltd, Yangtze Delta Drug Adv Res Inst, Nantong 226133, Peoples R China
推荐引用方式
GB/T 7714		 Li, Zeru,Xu, Huipeng,Wang, Siwen,et al. Standardization of nasal airway structure model of Chinese Han nationality for characterization of nasal formulation spatial deposition atlases[J]. ACTA PHARMACEUTICA SINICA B,2025,15(12):6698-6713.
APA Li, Zeru.,Xu, Huipeng.,Wang, Siwen.,Nie, Qin.,Jia, Bingqian.,...&Wu, Li.(2025).Standardization of nasal airway structure model of Chinese Han nationality for characterization of nasal formulation spatial deposition atlases.ACTA PHARMACEUTICA SINICA B,15(12),6698-6713.
MLA Li, Zeru,et al."Standardization of nasal airway structure model of Chinese Han nationality for characterization of nasal formulation spatial deposition atlases".ACTA PHARMACEUTICA SINICA B 15.12(2025):6698-6713.

入库方式： OAI收割

来源：上海药物研究所

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