Biomimetic cell membrane-mediated nanodelivery platform based on natural products: Emerging strategies for cancer combination therapy
文献类型：期刊论文
| 作者 | Jiang, Yingjie7,10; Hu, Zonglan6; Wei, Yuyu7; Su, Yufei7; Yang, Yanrui7; Aikedai, Aikepaer7; Liao, Weiwei7; Wei, Yuting7; Zeng, Xinyu1,2,3; Qian, Kun8 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2026-05-01 |
| 卷号 | 328页码:28 |
| 关键词 | Biomimetic cell membrane Nanomedicine Natural product Drug delivery Cancer combination therapy |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2025.123908 |
| 英文摘要 | The therapeutic limitations such as drug resistance, insufficient efficacy, metastasis, cancer heterogeneity, and severe side effects are frequently caused by the long duration of cancer monotherapy. In comparison, multimodal cancer combination therapy strategies hold great promise for countering these limitations. Recent studies increasingly demonstrate the distinct anti-cancer effects of natural products, boosting combined cancer therapies via multiple pathways. However, their therapeutic outcomes are significantly compromised by low bioavailability and poor targeting. Biomimetic cell membrane nanodelivery systems show excellent biocompatibility, enhanced physiological barrier penetration, and homologous targeting. Cell membranes extracted from erythrocytes, cancer cells, immune cells, and so on are often used to coat nanoparticles (NPs) to achieve multiple functions. As expected, the therapeutic effects of natural products are significantly enhanced by the delivery of biomimetic membranes. Here, the advantages of natural products in combating cancer and the preparation process of cell membrane-coated NPs are summarized. More importantly, the recent progress of cell membrane nanodelivery systems for encapsulating natural products in cancer combination therapy is discussed, highlighting the construction of biomimetic nanomedicines, targeted drug delivery, controlled drug release, enhanced anti-cancer efficacy, and underlying anti-cancer mechanisms. Further, the review contrasts the advantages of cell membrane biomimetic nanocarriers with other nanocarriers. Finally, the possibilities and challenges of clinical translation in this new field are discussed. |
| WOS关键词 | PHOTOTHERMAL SYNERGISTIC THERAPY ; POLYDOPAMINE NANOPARTICLES ; DELIVERY SYSTEM ; TUMOR ; DRUG ; ANTITUMOR ; ENHANCE ; NANOPLATFORM ; CHEMOTHERAPY ; METASTASIS |
| 资助项目 | National Natural Science Foundation of China[82204633] ; National Natural Science Foundation of China[82304880] ; Natural Science Foundation of Sichuan Province[2024NSFSC2112] ; Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine[2024-QNRC2-B28] ; Gansu Science and Technology Major Project[23ZDFA014] ; State Key Laboratory of Drug Research[SIMM0120231004] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB0830300] ; Talent Research Promotion Plan of Xinglin Scholar Discipline in Chengdu University of Traditional Chinese Medicine[QJRC2024021] ; China Scholarship Council (CSC)[202106270027] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001642446000001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322444]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Ding, Qihang; Yang, Lu; Cheng, Zhen; Luo, Kaipei |
| 作者单位 | 1.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, 1 Keyuan 4th Rd,Gaopeng St, Chengdu 610041, Sichuan, Peoples R China 2.Sichuan Univ, West China Hosp, Canc Ctr, 1 Keyuan 4th Rd,Gaopeng St, Chengdu 610041, Sichuan, Peoples R China 3.Collaborat Innovat Ctr Biotherapy, 1 Keyuan 4th Rd, Gaopeng St, Chengdu 610041, Sichuan, Peoples R China 4.Korea Univ, Dept Chem, Seoul 02841, South Korea 5.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 6.Fushun Peoples Hosp, Dept Rehabil Med, Zigong 643000, Peoples R China 7.Chengdu Univ Tradit Chinese Med, Sch Pharm, Sch Modern Chinese Med Ind, State Key Lab Southwestern Chinese Med Resources, Chengdu 611130, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 9.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 10.Sichuan Univ, State Key Lab Biotherapy & Canc Ctr, Lab Aging Res & Canc Drug Target, Natl Clin Res Ctr Geriatr,West China Hosp, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Yingjie,Hu, Zonglan,Wei, Yuyu,et al. Biomimetic cell membrane-mediated nanodelivery platform based on natural products: Emerging strategies for cancer combination therapy[J]. BIOMATERIALS,2026,328:28. |
| APA | Jiang, Yingjie.,Hu, Zonglan.,Wei, Yuyu.,Su, Yufei.,Yang, Yanrui.,...&Luo, Kaipei.(2026).Biomimetic cell membrane-mediated nanodelivery platform based on natural products: Emerging strategies for cancer combination therapy.BIOMATERIALS,328,28. |
| MLA | Jiang, Yingjie,et al."Biomimetic cell membrane-mediated nanodelivery platform based on natural products: Emerging strategies for cancer combination therapy".BIOMATERIALS 328(2026):28. |
入库方式： OAI收割
来源：上海药物研究所
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