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Polypeptide sono-adjuvant for ultrasound-activatable regulation of innate immunity and cancer vaccination therapy

文献类型：期刊论文

作者Chen, Fangmin1,6,7; Zhang, Huijuan1,7; Li, Shiqin1,7; Ren, Siyuan1,5,7; Huang, Lujia1,6,7; Guo, Yu1,7; Lai, Yi1,6,7; Cai, Zhixiong4; Liu, Xiaolong4; Xu, Zhiai3
刊名NATURE COMMUNICATIONS
出版日期2025-12-16
卷号17期号:1页码:20
DOI10.1038/s41467-025-66976-2
通讯作者Xu, Zhiai(zaxu@chem.ecnu.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要Spatiotemporally-controllable regulation of innate immunity in lymph node remains a critical challenge to implement effective cancer vaccination. Here we report an ultrasound-activatable strategy to precisely stimulate innate immunity activation in vivo. Mechanistically, ultrasound-triggered mechanical and oxidative forces synchronously activate innate immune pathways in antigen-presenting cells via calcium ion influx and mitochondria DNA release. We next design a polypeptide sono-adjuvant (SONA) library with adjustable physicochemical properties for lymph node-targeting delivery. The top-performed SONA specifically activates robust and durable innate immune responses in lymph node upon localized ultrasound stimulation. The combination of SONA-based vaccine with ultrasound stimulation induces about 3.0-fold higher antigen-specific T cell responses than conventional adjuvant-based vaccines. Moreover, in syngeneic mouse models of orthotopic breast and liver tumors, the combination of SONA-based neoantigen vaccine with ultrasound stimulation markedly boosts immune checkpoint blockade therapy to suppress tumor growth and distant metastasis. Collectively, the polypeptide sono-adjuvant offers great promise for precise regulation of innate immunity and cancer vaccine therapy.
WOS关键词COMBINATION ; INTERFERON
资助项目National Natural Science Foundation of China (National Science Foundation of China)[U22A20328] ; National Natural Science Foundation of China (National Science Foundation of China)[W2412035] ; National Natural Science Foundation of China (National Science Foundation of China)[22074043]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001657068500001
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/322554]  
专题中国科学院上海药物研究所
通讯作者Xu, Zhiai; Yu, Haijun
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai, Peoples R China
2.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai, Shandong, Peoples R China
3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai, Peoples R China
4.Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Fangmin,Zhang, Huijuan,Li, Shiqin,et al. Polypeptide sono-adjuvant for ultrasound-activatable regulation of innate immunity and cancer vaccination therapy[J]. NATURE COMMUNICATIONS,2025,17(1):20.
APA Chen, Fangmin.,Zhang, Huijuan.,Li, Shiqin.,Ren, Siyuan.,Huang, Lujia.,...&Yu, Haijun.(2025).Polypeptide sono-adjuvant for ultrasound-activatable regulation of innate immunity and cancer vaccination therapy.NATURE COMMUNICATIONS,17(1),20.
MLA Chen, Fangmin,et al."Polypeptide sono-adjuvant for ultrasound-activatable regulation of innate immunity and cancer vaccination therapy".NATURE COMMUNICATIONS 17.1(2025):20.

入库方式： OAI收割

来源：上海药物研究所

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