Rosemary oil-based microemulsion co-delivering quercetin and adenosine promotes hair regeneration in androgenetic alopecia via multiple actions
文献类型：期刊论文
| 作者 | Cai, Wenli1,2,3; Cai, Keneng1; Li, Zeyu2; Zhang, Xiaoru2; Gong, Shuqing2; Liao, Lingling2; Gao, Jiaying2; Xu, Quangang2; Liu, Ergang2; Liang, Jianming1 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2026-01-15 |
| 卷号 | 528页码:21 |
| 关键词 | Quercetin Rosemary oil Adenosine Microemulsion Hair regeneration Androgenetic alopecia |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2025.172193 |
| 通讯作者 | Liu, Ergang(liuergang@zidd.ac.cn) ; Liang, Jianming(liangjianming@gzucm.edu.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | The pathogenesis of androgenetic alopecia (AGA) is driven by heightened androgen receptor signaling, alongside contributing factors of oxidative stress, follicular inflammation, and impaired perifollicular angiogenesis. Existing treatments such as minoxidil and finasteride suffer from limited efficacy, systemic side effects, and high relapse rates. In this study, we developed a rosemary oil (RO)-based microemulsion (QAR ME) for the co-delivery of quercetin (QT) and adenosine (AD) to synergistically target multiple pathological pathways of AGA. Here, RO can not only serve as a component of the oil phase but also function as a functional excipient with inherent antioxidant activity. The optimized QAR ME formulation demonstrated high stability, a small uniform particle size (24.98 +/- 0.41 nm). It not only improved the solubility of QT but also enhanced the skin penetration of each active component. In vitro and in vivo evaluations revealed that QAR ME effectively attenuated oxidative stress, suppressed inflammatory responses, promoted angiogenesis, and activated the Wnt/beta-catenin pathway, leading to enhanced hair follicle regeneration. It is worth noting that during the 28-day continuous treatment, QAR ME did not show any adverse reactions, which indicates that this therapy has the potential for long-term treatment of AGA. These findings indicate that QAR ME is a promising topical nanotherapy for the safe and effective treatment of AGA. |
| WOS关键词 | DERMAL PAPILLA CELLS ; PROSTATE-CANCER ; GROWTH ; MINOXIDIL ; DIFFERENTIATION ; NANOPARTICLES ; FOLLICLES ; RECEPTOR ; VEGF ; SKIN |
| 资助项目 | National Key Research and Development Program of China[2022YFE0203600] ; National Key Research and Development Program of China[2024YFA1210200] ; National Key Research and Development Program of China[2025YFE0107400] ; National Key Research and Development Program of China[083GJHZ2023012FN] ; National Key Research and Development Program of China[083GJHZ2023021GC] ; International Partner-ship Program of the Chinese Academy of Sciences, CAS[2024VBB0004] ; NSFC[82341232] ; NSFC[82404549] ; NSFC[82174456] ; Department of Science and Tech-nology of Guangdong Province[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD202201] ; Second batch of so-cial welfare and basic research projects of Zhongshan city[2023B2033] ; Program of Shanghai Committee of Science and Technology[22S21902900] ; Natural Science Foundation of Shanghai Municipal[24ZR1477500] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001658277900001 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322575]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Ergang; Liang, Jianming; Huang, Yongzhuo |
| 作者单位 | 1.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, Guangzhou 510450, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Guangzhou Univ Chinese Med, Guangzhou 510006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Wenli,Cai, Keneng,Li, Zeyu,et al. Rosemary oil-based microemulsion co-delivering quercetin and adenosine promotes hair regeneration in androgenetic alopecia via multiple actions[J]. CHEMICAL ENGINEERING JOURNAL,2026,528:21. |
| APA | Cai, Wenli.,Cai, Keneng.,Li, Zeyu.,Zhang, Xiaoru.,Gong, Shuqing.,...&Huang, Yongzhuo.(2026).Rosemary oil-based microemulsion co-delivering quercetin and adenosine promotes hair regeneration in androgenetic alopecia via multiple actions.CHEMICAL ENGINEERING JOURNAL,528,21. |
| MLA | Cai, Wenli,et al."Rosemary oil-based microemulsion co-delivering quercetin and adenosine promotes hair regeneration in androgenetic alopecia via multiple actions".CHEMICAL ENGINEERING JOURNAL 528(2026):21. |
入库方式： OAI收割
来源：上海药物研究所
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