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Surface engineering quantum dots emitting agents for NIR-II fluorescence imaging-guided rapid diagnosis of bone fracture

文献类型：期刊论文

作者Liu, Sha1,4; Tian, Nannan1,4; Dong, Wenhong4; Zhang, Shanshan4; Zhao, Shuxian1,4; Gao, Hui-quan2,3; Suo, Yongkuan3,4; Song, Zhaorui4; Cheng, Zhen1,3,4
刊名MATERIALS TODAY CHEMISTRY
出版日期2026
卷号51页码:11
关键词NIR-II fluorescence imaging Quantum dots Surface engineering strategy Polystyrene microspheres Fracture rapid diagnosis
ISSN号2468-5194
DOI10.1016/j.mtchem.2025.103285
英文摘要Rapid and accurate diagnosis of suspected fracture is critical for the entire treatment process and the final outcome. Limited by the inherent defects of conventional bone imaging techniques, the development of non-invasive optical imaging strategy is emerging as a new trend. Herein, three types of Ag-based NIR-II QDs with low toxicity and high photoluminescent quantum yield (PLQY) are synthesized using tailored synthetic protocols, and then the corresponding NIR-II QDs polystyrene (PS) microspheres (Ag2S PS, Ag2Se PS, AgAuSe PS) with favorable dispersibility and photostability are fabricated via a convenient surface engineering strategy. In vitro assays reveal that AgAuSe PS probes have superior tissue penetration depth (>3 mm) and good bio-safety. In vivo NIR-II fluorescence imaging results show that as an efficient NIR-II emitting agent, AgAuSe PS probes possess rapid bone imaging capability (only 10 min), high signal-to-noise ratio (SNR = 6.35), and excellent biocompatibility. Subsequently, we successfully achieve NIR-II fluorescence imaging-guided rapid and accurate diagnosis of tibial fracture in mice model, and a comprehensive performance comparison further demonstrates the superior characteristics of the proposed AgAuSe PS probes relative to previously reported NIR-II bone imaging probes. Overall, these findings will contribute to provide a significant non-invasive, fast and high-contrast visualization option of bone fracture.
资助项目Key R & D Program of Shandong Province, China[2024CXPT028] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB0830000] ; Shandong Provincial Natural Science Foundation[ZR2022QH212] ; Shandong Laboratory Program[SYS202205] ; Science and Technology Innovation Development Plan of Yantai City of China[2024YD055]
WOS研究方向Chemistry ; Materials Science
语种英语
WOS记录号WOS:001660513800001
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/322605]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Gao, Hui-quan; Suo, Yongkuan; Song, Zhaorui; Cheng, Zhen
作者单位1.Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Peoples R China
2.Qingdao Univ, Affiliated Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai 264117, Shandong, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Sha,Tian, Nannan,Dong, Wenhong,et al. Surface engineering quantum dots emitting agents for NIR-II fluorescence imaging-guided rapid diagnosis of bone fracture[J]. MATERIALS TODAY CHEMISTRY,2026,51:11.
APA Liu, Sha.,Tian, Nannan.,Dong, Wenhong.,Zhang, Shanshan.,Zhao, Shuxian.,...&Cheng, Zhen.(2026).Surface engineering quantum dots emitting agents for NIR-II fluorescence imaging-guided rapid diagnosis of bone fracture.MATERIALS TODAY CHEMISTRY,51,11.
MLA Liu, Sha,et al."Surface engineering quantum dots emitting agents for NIR-II fluorescence imaging-guided rapid diagnosis of bone fracture".MATERIALS TODAY CHEMISTRY 51(2026):11.

入库方式： OAI收割

来源：上海药物研究所

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