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Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection

文献类型：期刊论文

作者Lu, Tiantian1,2; Liu, Li1,2; Wang, Ping1,2; Chen, Zhe1,2; Wu, Pei1,2; Chen, Jiawei1,2; Peng, Guilin12; Guan, Ruijuan11; Wang, Chaoqun10; Sui, Pengfei9
刊名CELL STEM CELL
出版日期2026-01-08
卷号33期号:1页码:24
ISSN号1934-5909
DOI10.1016/j.stem.2025.12.005
英文摘要Severe respiratory viral infections lead to extensive damage to the alveolar epithelium and also induce a robust immune response. How the immune microenvironment interacts with lung stem/progenitor cells and impacts alveolar regeneration is poorly understood. Here, we found that dysplastic KRT5+ basal-like cells, which emerge after severe viral infections, contribute to the recruitment and sequestration of CD4+ effector and CD8+ T cells in the lung after viral clearance in a CXCR3-and integrin alpha 4 beta 7-dependent manner. Persistent CD4+ effector and CD8+ T cells impair alveolar regeneration mediated via airway secretory cells by secreting IFN gamma, thereby inhibiting lung functional repair. Importantly, anti-IFN gamma treatment improves alveolar regeneration and lung function in vivo. Overall, our study reveals the pathogenetic role of dysplastic KRT5+ cells in alveolar regeneration, serving as a niche for tissue-resident lymphocytes that specifically inhibit alveolar regeneration. Additionally, our findings provide a potential therapeutic strategy to improve alveolar regeneration after viral pneumonia.
WOS关键词NEUROEPITHELIAL BODY MICROENVIRONMENT ; AIRWAY STEM-CELLS ; PULMONARY-FIBROSIS ; T-CELLS ; LUNG ; PROGENITORS ; DIFFERENTIATION ; MAINTENANCE ; CONTRIBUTE ; RESPONSES
资助项目Precision Medicine at ShanghaiTech University ; ShanghaiTech University start-up funds ; HPC Platform of ShanghaiTech University
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:001665467800005
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/322673]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Zhao, Jincun; Ren, Tao; Xi, Ying
作者单位1.ShanghaiTech Univ, State Key Lab Adv Med Mat & Devices, Shanghai 201210, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
3.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
4.Guangzhou Lab Bioisl, Guangzhou 510005, Guangdong, Peoples R China
5.Fudan Univ, Zhongshan Hosp, Dept Pulm Med, Shanghai Key Lab Lung Inflammat & Injury, Shanghai 200032, Peoples R China
6.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Dept Resp & Clin Care Med, Shanghai 200233, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, Unit Resp Infect & Immun, Shanghai 200031, Peoples R China
8.Shanghai Clin Res & Trial Ctr, Shanghai 201210, Peoples R China
9.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, Chinese Acad Sci,State Key Lab Multicell Syst, Shanghai 200031, Peoples R China
10.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Tiantian,Liu, Li,Wang, Ping,et al. Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection[J]. CELL STEM CELL,2026,33(1):24.
APA Lu, Tiantian.,Liu, Li.,Wang, Ping.,Chen, Zhe.,Wu, Pei.,...&Xi, Ying.(2026).Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection.CELL STEM CELL,33(1),24.
MLA Lu, Tiantian,et al."Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection".CELL STEM CELL 33.1(2026):24.

入库方式： OAI收割

来源：上海药物研究所

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