Development of hydrolytically stable γ-cyclodextrin-based microparticles derived from MOFs for sustained pulmonary drug delivery
文献类型：期刊论文
| 作者 | Wang, Caifen1,2; Zhang, Guoqing5; Nie, Qin1,2; Peng, Ningning2,5; Wu, Li1,3,5; Ren, Xiaohong1; Wu, Qian1,2; Bello, Mubarak G.4; Xu, Guanghong5; Yang, Rui3 |
| 刊名 | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
 |
| 出版日期 | 2026-03-01 |
| 卷号 | 117页码:11 |
| 关键词 | Covalent cyclodextrin particles derived from MOFs Pulmonary drug delivery Sustained release Drug carrier Dexamethasone |
| ISSN号 | 1773-2247 |
| DOI | 10.1016/j.jddst.2026.108064 |
| 通讯作者 | Zhang, Jiwen(jwzhang@simm.ac.cn) ; Sun, Lixin(slx04@163.com) |
| 英文摘要 | Chronic lung diseases remain challenging to treat due to inefficient drug delivery and rapid clearance from the respiratory tract. In this study, covalently crosslinked gamma-cyclodextrin particles (CDPs) were synthesized from gamma-cyclodextrin metal-organic frameworks (MOFs) via esterification with diphenyl carbonate. The obtained CDPs exhibited a uniform particle size (D50 = 1.19 mu m) and a crosslinking degree of approximately 4. Structural and physicochemical characterizations indicated the successful covalent transformation, preserved internal cavities, and enhanced aqueous stability. Dexamethasone (DEX) was encapsulated within CDPs to form DEX@CDP complexes. Next generation impactor testing revealed superior aerosolization with fine particle fractions of 85.36 % (CDP) and 67.01 % (DEX), ensuring efficient deposition in the deep lung region. In vitro release studies showed sustained release, with less than 31 % of DEX released over 24 h. In vivo pharmacokinetic analysis demonstrated that DEX@CDP doubled mean residence time (MRT) and elimination half-life (t1/2) compared to inhaled DEX@MOF and intragastric DEX. Furthermore, CDPs exhibited excellent cytocompatibility toward A549 and J774A.1 cells (20-500 mu g/mL) and favorable in vivo biocompatibility. These results indicate that the hydrolytically stable, cavity-retaining CDPs derived from MOFs are promising inhalable carriers for efficient and sustained pulmonary drug delivery. |
| WOS关键词 | CARRIERS ; RELEASE ; POLYMER ; DEXAMETHASONE ; MICROSPHERES ; FORMULATION ; SORPTION ; SIZE |
| 资助项目 | National Science and Technology Major Project of China[2025ZD1802900] ; Natural Science Foundation of China[82273863] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001684028000001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322848]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jiwen; Sun, Lixin |
| 作者单位 | 1.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 3.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China 4.Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China 5.Jiangsu Yungou Pharmaceut Technol Co Ltd, Yangtze Delta Drug Adv Res Inst, Nantong 226133, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Caifen,Zhang, Guoqing,Nie, Qin,et al. Development of hydrolytically stable γ-cyclodextrin-based microparticles derived from MOFs for sustained pulmonary drug delivery[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2026,117:11. |
| APA | Wang, Caifen.,Zhang, Guoqing.,Nie, Qin.,Peng, Ningning.,Wu, Li.,...&Sun, Lixin.(2026).Development of hydrolytically stable γ-cyclodextrin-based microparticles derived from MOFs for sustained pulmonary drug delivery.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,117,11. |
| MLA | Wang, Caifen,et al."Development of hydrolytically stable γ-cyclodextrin-based microparticles derived from MOFs for sustained pulmonary drug delivery".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 117(2026):11. |
入库方式： OAI收割
来源：上海药物研究所
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