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Withanolides from Physalis angulata as Potent Antimelanoma Agents: Activation of the p53 Pathway In Vitro and In Vivo

文献类型：期刊论文

作者Hu, Bintao1,7,8; Li, Han5,6,8; Tang, Chunping7,8; Ke, Chang-Qiang7,8; Ding, Jian5,6,8; Yao, Sheng3,4,8; Xie, Zuoquan4,8; Ye, Yang2,4,5,8
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2026-02-18
卷号74期号:6页码:5237-5255
关键词withanolide Physalis angulata antimelanoma p53 signaling pathway
ISSN号0021-8561
DOI10.1021/acs.jafc.5c12654
英文摘要Phytochemical investigation of the aerial parts of Physalis angulata led to the isolation of 15 undescribed withanolides, including an unprecedented 2,3-seco-1,3-cyclo-physalin (1) and a C27-nor-physalin (12), along with two known analogues (16 and 17). Their planar structures and absolute configurations were established by comprehensive spectroscopic analysis, together with single crystal X-ray diffraction, ECD spectroscopy, and DFT NMR or TDDFT ECD calculations. All isolates were evaluated for their antimelanoma activity. In vitro, compounds 6 and 14 markedly inhibited the proliferation of B16F10 and A375 cells by inducing cell-cycle arrest and apoptosis via activation of the p53 signaling pathway, which was further confirmed by Trp53 knockout in B16F10 cells. In vivo, compound 6 significantly suppressed the growth of B16F10 and A375 subcutaneous xenografts in mice and concomitantly activated intratumoral p53 signaling pathway. These findings indicated withanolides isolated from P. angulata exert antimelanoma effects by activating the p53 signaling pathway.
资助项目Ministry of Science and Technology of the People's Republic of China[2024YFE0117200] ; Natural Science Foundation of Zhejiang Province[LJHSQY26H300002] ; Basic and Applied Basic Research Foundation of Guangdong Province[2024A1515011348] ; National Natural Science Foundation of China[82173696] ; National Key Research and Development Program of China[2022YFE0203600] ; Zhongshan Science and Technology Bureau[CXTD2023010]
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
WOS记录号WOS:001684022200001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/322851]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Yao, Sheng; Xie, Zuoquan; Ye, Yang
作者单位1.Zhejiang Chinese Med Univ, Jinhua Acad, Jinhua 321000, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, China Serbia Belt & Rd Joint Lab Nat Prod & Drug, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
6.Lingang Lab, Shanghai 200031, Peoples R China
7.Chinese Acad Sci, Nat Prod Chem Dept, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
8.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Bintao,Li, Han,Tang, Chunping,et al. Withanolides from Physalis angulata as Potent Antimelanoma Agents: Activation of the p53 Pathway In Vitro and In Vivo[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2026,74(6):5237-5255.
APA Hu, Bintao.,Li, Han.,Tang, Chunping.,Ke, Chang-Qiang.,Ding, Jian.,...&Ye, Yang.(2026).Withanolides from Physalis angulata as Potent Antimelanoma Agents: Activation of the p53 Pathway In Vitro and In Vivo.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,74(6),5237-5255.
MLA Hu, Bintao,et al."Withanolides from Physalis angulata as Potent Antimelanoma Agents: Activation of the p53 Pathway In Vitro and In Vivo".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 74.6(2026):5237-5255.

入库方式： OAI收割

来源：上海药物研究所

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