中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Skin-penetrating peptides derived from computational simulation improve transdermal absorption and facilitate topical treatment of melanoma

文献类型：期刊论文

作者Du, Sanjiang5,6,7; Wang, Hanlin4,5,6,7; Geng, Feiyang5,6,7; Zhang, Zongxu5,6,7; Liu, Chenghao5,6,7; Lu, Weiyue3,5,6,7; Wei, Gang1,2,3,5,6,7
刊名ACTA PHARMACEUTICA SINICA B
出版日期2026-02-01
卷号16期号:2页码:1140-1154
关键词Cell-penetrating peptides Cutaneous administration Computational simulation Melanoma Floxuridine AlphaFold Transdermal drug delivery Penetratin
ISSN号2211-3835
DOI10.1016/j.apsb.2025.12.026
通讯作者Wei, Gang(weigang@shmu.edu.cn)
英文摘要Transdermal drug delivery relies heavily on the skin permeability of therapeutic agents. In order to develop a peptide-based delivery strategy for promoting transdermal absorption, the key physicochemical factors influencing skin permeability are first identified through cell-penetrating peptides (CPPs) screening and computational simulation. Penetratin exhibits the most outstanding permeability and safety among CPPs from various origins, and positive surface patch area emerges as the key property correlated with skin permeability of the peptides. Based on these findings, a precise model to predict skin permeability of the peptides is established, leading to the computational redesign of penetratin's amino acid sequence. The transdermal delivery efficiency of optimized penetratin derivative (589WP) is significantly improved in vitro compared with wild-type penetratin and visualized through in vivo imaging. Furthermore, the anti-metabolic drug floxuridine (FUdR) is covalently conjugated with 589WP via ester linkage, leading to accelerated FUdR release due to esterase degradation. Subsequently, this conjugate is formulated into an anhydrous gel, which significantly inhibits melanoma growth with topical application, outperforming a higher dose of free FUdR without observed skin irritancy or toxicity. The peptide prediction and design approaches established herein hold great potential for advancing transdermal drug delivery. 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
WOS关键词PROTEIN TRANSDUCTION ; DELIVERY ; ENHANCERS ; ARGININE ; 5-FLUOROURACIL ; FLUOROURACIL ; PERMEATION ; MECHANISMS ; DESIGN
资助项目National Natural Science Foundation of China[82273864] ; National Key RD Program China[2024YFA1210203] ; Seed Program for Medical New Technology Research and Translation of the Shanghai Municipal Health Commission[2025ZZ1020] ; Shanghai Science and Technology Program[21ZR1407100] ; Shanghai Science and Technology Program[21S11905300]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001685456300001
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/322860]  
专题中国科学院上海药物研究所
通讯作者Wei, Gang
作者单位1.Quzhou Fudan Inst, Quzhou 324003, Peoples R China
2.Shanghai Engn Res Ctr ImmunoTherapeut, Shanghai 201203, Peoples R China
3.Fudan Univ, Inst Integrat Med, Shanghai 200040, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
5.Natl Key Lab Adv Drug Formulat Overcoming Delivery, Shanghai 201203, Peoples R China
6.Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China
7.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Du, Sanjiang,Wang, Hanlin,Geng, Feiyang,et al. Skin-penetrating peptides derived from computational simulation improve transdermal absorption and facilitate topical treatment of melanoma[J]. ACTA PHARMACEUTICA SINICA B,2026,16(2):1140-1154.
APA Du, Sanjiang.,Wang, Hanlin.,Geng, Feiyang.,Zhang, Zongxu.,Liu, Chenghao.,...&Wei, Gang.(2026).Skin-penetrating peptides derived from computational simulation improve transdermal absorption and facilitate topical treatment of melanoma.ACTA PHARMACEUTICA SINICA B,16(2),1140-1154.
MLA Du, Sanjiang,et al."Skin-penetrating peptides derived from computational simulation improve transdermal absorption and facilitate topical treatment of melanoma".ACTA PHARMACEUTICA SINICA B 16.2(2026):1140-1154.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。