Enhanced bioavailability of anemoside B4 by dry powder inhalation mitigates high-altitude acute lung injury
文献类型：期刊论文
| 作者 | Wen, Yuewen1,4,5; Teng, Yupu2,4; Zheng, Shiyu1,4; Shao, Shuang4,5; Li, Feng3,4; Wang, Caifen4; Ren, Xiaohong4; Feng, Yulin5; Zhang, Jiwen1,4,5 |
| 刊名 | PHYTOMEDICINE
 |
| 出版日期 | 2026-03-01 |
| 卷号 | 152页码:10 |
| 关键词 | Anemoside B4 Pulmonary delivery Antisolvent precipitation Dry powder inhalers High-altitude hypoxia Acute lung injury |
| ISSN号 | 0944-7113 |
| DOI | 10.1016/j.phymed.2026.157788 |
| 通讯作者 | Ren, Xiaohong(xhren@simm.ac.cn) ; Feng, Yulin(fengyulin2003@126.com) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | Background: Anemoside B4 (AB4), a pentacyclic triterpenoid saponin, exhibits potent anti-inflammatory and antioxidant activities; however, it has poor oral bioavailability. Hypobaric hypoxia (HH) can induce high-altitude acute lung injury (ALI) through inflammatory response and oxidative stress pathways, highlighting the need for effective targeted therapies. Purpose: This study aimed to develop an AB4 dry powder inhaler (DPI) for improving lung deposition and bioavailability, and to evaluate its prophylactic efficacy against high-altitude ALI. Methods: AB4 inhalable microparticles were prepared by antisolvent precipitation and developed into a DPI formulation. Aerodynamic properties were characterized by mass median aerodynamic diameter (D50) and fine particle fraction (FPF). Anti-inflammatory activity was assessed in vitro using an LPS-stimulated alveolar macrophage model. An in vivo HH/LPS co-induced rat model of high-altitude ALI was established to investigate pharmacodynamic effects and bioavailability. Results: AB4 DPI exhibited excellent aerodynamics (D50: 1.92 mu m; FPF: 62.86 +/- 10.51%). It inhibited LPSinduced release of TNF-alpha, IL-6, and IL-1 beta. Inhalation of AB4 DPI attenuated pulmonary inflammation in vivo and restored oxidative balance by reducing malondialdehyde (MDA) and myeloperoxidase (MPO) levels while increasing superoxide dismutase (SOD) activity. The absolute bioavailability reached 18.61 +/- 5.81%, representing a 74.44-fold increase compared to oral administration (0.25 +/- 0.19%). Conclusion: This study successfully combined a traditional Chinese medicine component with advanced particle engineering technology to develop an efficient non-invasive pulmonary drug delivery system. AB4 DPI retained bioactivity while markedly addressing the pharmacokinetic limitations of oral administration, offering a clinically promising prophylactic strategy against high-altitude ALI. |
| WOS关键词 | ANTISOLVENT PRECIPITATION ; PULMONARY-EDEMA |
| 资助项目 | Special Zone Construction Project for Traditional Chinese Medicine (New Drug Discovery Direction) at Jiangxi University of Chinese Medicine[TQ-28] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:001683327100001 |
| 出版者 | ELSEVIER GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322863]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ren, Xiaohong; Feng, Yulin; Zhang, Jiwen |
| 作者单位 | 1.Nanjing Univ Chinese Med, Nanjing 210023, Peoples R China 2.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China 5.Jiangxi Univ Chinese Med, Nanchang 330006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Yuewen,Teng, Yupu,Zheng, Shiyu,et al. Enhanced bioavailability of anemoside B4 by dry powder inhalation mitigates high-altitude acute lung injury[J]. PHYTOMEDICINE,2026,152:10. |
| APA | Wen, Yuewen.,Teng, Yupu.,Zheng, Shiyu.,Shao, Shuang.,Li, Feng.,...&Zhang, Jiwen.(2026).Enhanced bioavailability of anemoside B4 by dry powder inhalation mitigates high-altitude acute lung injury.PHYTOMEDICINE,152,10. |
| MLA | Wen, Yuewen,et al."Enhanced bioavailability of anemoside B4 by dry powder inhalation mitigates high-altitude acute lung injury".PHYTOMEDICINE 152(2026):10. |
入库方式： OAI收割
来源：上海药物研究所
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