Lipid metabolism in homeostasis and disease
文献类型：期刊论文
| 作者 | Li, Zhenghao2,8; Deng, Wende2,7; Yang, Lanxuan2,8; Tang, Changheng2,8; Yue, Jian-Min6; Monteiro, Olivia3,4,5; Baptista-Hon, Daniel T.3,4,5; Li, Ting1,2,4,7,8 |
| 刊名 | SIGNAL TRANSDUCTION AND TARGETED THERAPY
 |
| 出版日期 | 2026-02-16 |
| 卷号 | 11期号:1页码:38 |
| ISSN号 | 2095-9907 |
| DOI | 10.1038/s41392-025-02357-x |
| 英文摘要 | Lipid metabolism is essential for maintaining cellular homeostasis, and its dysregulation is linked to various diseases, including cancer, cardiovascular disease, and diabetes. Immune cells, such as macrophages, T cells, B cells, and neutrophils, rely on lipid metabolism for their function, which impacts both innate and adaptive immune responses. Understanding how lipid metabolism influences immune cells is crucial, as it can reveal new therapeutic opportunities for immune-mediated diseases. In this review, we provide a retrospective summary of the research history and milestone events in lipid metabolism research and highlight the importance of lipid metabolism in immune cells. In addition to discussing the various lipid functions, transport, and signaling pathways involved in lipid metabolism, we mainly explore the regulation of immune cell behavior by lipid metabolism, focusing on the roles of lipid metabolites in immune cell proliferation, differentiation, and activation. We further highlight multilevel regulatory mechanisms, including genetic, epigenetic, posttranscriptional, and posttranslational regulation, and their impact on immune cell function. Additionally, we discuss the role of lipid metabolism in diseases such as autoimmune diseases, cancer, neurodegenerative diseases, cardiovascular diseases, aging, and metabolic disorders. Finally, we summarize therapeutic strategies targeting lipid metabolism, the progress of global clinical trials, and future research directions, including lipid-derived biomarkers and innovative therapeutic approaches. |
| WOS关键词 | POLYUNSATURATED FATTY-ACIDS ; LOW-DENSITY-LIPOPROTEIN ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; INFLAMMATORY-BOWEL-DISEASE ; COA REDUCTASE INHIBITOR ; FOAM CELL-FORMATION ; T-CELLS ; REGULATORY T ; SPHINGOSINE 1-PHOSPHATE ; CARDIOVASCULAR-DISEASE |
| 资助项目 | The Science and Technology Development Fund, Macau SAR (0018/2023/AMJ, 006/2023/SKL, 0003/2021/AKP, 0043/2024/AGJ), and the National Key Research and Development Program of China (2023YFE0206100). |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001690243600001 |
| 出版者 | SPRINGERNATURE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322951]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Li, Ting |
| 作者单位 | 1.Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, Macau, Peoples R China 2.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China 3.Macau Univ Sci & Technol, Fac Med, Macau, Peoples R China 4.Macau Univ Sci & Technol, Macau Inst Artificial Intelligence Med, Macau, Peoples R China 5.Univ Dundee, Sch Med, Dundee, Scotland 6.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China 7.Macau Univ Sci & Technol, Fac Med, Sch Pharm, Macau, Peoples R China 8.Macau Univ Sci & Technol, Fac Chinese Med, Macau, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhenghao,Deng, Wende,Yang, Lanxuan,et al. Lipid metabolism in homeostasis and disease[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2026,11(1):38. |
| APA | Li, Zhenghao.,Deng, Wende.,Yang, Lanxuan.,Tang, Changheng.,Yue, Jian-Min.,...&Li, Ting.(2026).Lipid metabolism in homeostasis and disease.SIGNAL TRANSDUCTION AND TARGETED THERAPY,11(1),38. |
| MLA | Li, Zhenghao,et al."Lipid metabolism in homeostasis and disease".SIGNAL TRANSDUCTION AND TARGETED THERAPY 11.1(2026):38. |
入库方式： OAI收割
来源：上海药物研究所
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