Phytochemical and biological studies on rare and endangered plants endemic to China. Part XLIX. Terpenoids and phenylpropanoid-substituted flavan-3-ols from the leaves of Camellia petelotii (golden-flower tea) and their bioactivities
文献类型：期刊论文
| 作者 | Zhao, Ze-Yu2,3; Wang, Can2; Jiang, Zhe-Lu2; Wan, Jiang2; Xiong, Juan3; Zang, Yi4; Choo, Yeun-Mun1; Li, Jia4; Hu, Jin-Feng2,3 |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2026-06-01 |
| 卷号 | 246页码:11 |
| 关键词 | Camellia petelotii Theaceae Guaiane-type sesquiterpenoids Phenylpropanoid-substituted flavan-3-ol Triterpenoids Anti-inflammatory activity Anti-ACL activity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2026.114808 |
| 英文摘要 | Camellia petelotii (Merr.) Sealy, commonly known as golden-flower tea, is an endangered yellow-flowering species of the genus Camellia (Theaceae). As a medicine and food homology (MFH) plant, it possesses significant medicinal and edible value. However, because the chemical constituents of C. petelotii have rarely been investigated, its potential medicinal and nutritional benefits remain poorly understood, hindering its further utilization. In this study, a comprehensive phytochemical investigation was conducted on the EtOAc-soluble fraction of a 90% MeOH extract derived from the leaves of C. petelotii, resulting in the isolation and characterization of five previously undescribed (1-5) and 19 known (6-24) compounds. Among these compounds, campetelolides A (1) and B (2) are identified as guaianolides bearing a 2-methyl-2-butenoxyl moiety. Campetelols A (3), B (4), and C (5) are classified as phenylpropanoid-substituted flavan-3-ols. The chemical structures and absolute configurations of these metabolites were elucidated through spectroscopic techniques, supported by calculated NMR data, combined with DP4+ analysis, as well as by comparison of calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1, 2, and eupachinilide I (6) exhibited anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW 264.7 cells by suppressing nitric oxide (NO) production, with IC50 values of 5.8, 4.8, and 4.8 mu M, respectively. In addition, compound 2 and 3 beta,11 alpha,12,21 beta-tetrahydroxy-22-oxours12-en-24-oic acid methyl ester (7) inhibited ATP-citrate lyase (ACL), exhibiting IC50 values of 11.2 and 9.3 mu M, respectively. The findings highlight the therapeutic potential of the endangered plant C. petelotii, offering prospects for the discovery of novel bioactive agents while simultaneously emphasizing the importance of its conservation and sustainable utilization. |
| WOS关键词 | ANTIINFLAMMATORY ACTIVITIES ; CONSTITUENTS ; INFLAMMATION ; ANTIOXIDANT ; INHIBITORS ; SINENSIS ; SESQUITERPENOIDS ; TRITERPENOIDS ; EPICATECHINS ; DERIVATIVES |
| 资助项目 | Zhejiang Provincial Natural Science Foundation of China[LY23H300001] ; Na-tional Natural Science Foundation of China[21937002] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001688221300001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322957]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Hu, Jin-Feng |
| 作者单位 | 1.Univ Malaya, Fac Sci, Chem Dept, Kuala Lumpur 50603, Malaysia 2.Taizhou Univ, Inst Nat Med & Hlth Prod, Sch Pharmaceut Sci, Key Lab Endangered Plants Sustainable Utilizat Tai, Taizhou 318000, Zhejiang, Peoples R China 3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Ze-Yu,Wang, Can,Jiang, Zhe-Lu,et al. Phytochemical and biological studies on rare and endangered plants endemic to China. Part XLIX. Terpenoids and phenylpropanoid-substituted flavan-3-ols from the leaves of Camellia petelotii (golden-flower tea) and their bioactivities[J]. PHYTOCHEMISTRY,2026,246:11. |
| APA | Zhao, Ze-Yu.,Wang, Can.,Jiang, Zhe-Lu.,Wan, Jiang.,Xiong, Juan.,...&Hu, Jin-Feng.(2026).Phytochemical and biological studies on rare and endangered plants endemic to China. Part XLIX. Terpenoids and phenylpropanoid-substituted flavan-3-ols from the leaves of Camellia petelotii (golden-flower tea) and their bioactivities.PHYTOCHEMISTRY,246,11. |
| MLA | Zhao, Ze-Yu,et al."Phytochemical and biological studies on rare and endangered plants endemic to China. Part XLIX. Terpenoids and phenylpropanoid-substituted flavan-3-ols from the leaves of Camellia petelotii (golden-flower tea) and their bioactivities".PHYTOCHEMISTRY 246(2026):11. |
入库方式： OAI收割
来源：上海药物研究所
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