Placidenes G-J, Bioactive γ-Pyrone Derivatives From the Marine Mollusk Placida dendritica
文献类型：期刊论文
| 作者 | Wang, Hao2,3; Li, Wen-Xuan3; Ru, Chao2; Gao, Zhen3; Li, Xu-Wen1,2,3 |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2026 |
| 卷号 | 23期号:1页码:8 |
| 关键词 | anti-inflammatory activity chiral separation marine natural products Placida dendritica gamma-pyrone derivatives |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202503208 |
| 通讯作者 | Li, Xu-Wen(xwli@simm.ac.cn) |
| 英文摘要 | Three pairs of undescribed enantiomeric gamma-pyrone derivatives placidenes G-I (1-3), together with two new congeners placidene J (4)/isoplacidene J (5) and two known compounds 6 and 7, were isolated from the marine mollusk Placida dendritica. Compounds 1a/1b-3a/3b were further separated by chiral-phase high-performance liquid chromatography. The structures were elucidated by comprehensive spectroscopic analysis, high-resolution electrospray ionization mass spectrometry, time-dependent density functional theory/electronic circular dichroism calculation, and X-ray diffraction analysis. In bioassays, compounds 1-5 exhibited moderate nitric oxide inhibition from 28.2% to 51.9% on RAW264.7 inflammatory cells at 20 mu M without notable cytotoxicity. |
| 资助项目 | 2025 Annual Self-deployment Project of State Key Laboratory of Chemical Biology[SKLCB-2025-06] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB1060000] ; Natural Science Foundation of China[42576087] ; Key Marine Service Industry Program of Shandong Province ; Key R&D Program of Shandong Province[2024CPT028] ; Key R&D Program of Shandong Province[2025CXPT012] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001680480200028 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322960]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Xu-Wen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai, Peoples R China 2.Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hao,Li, Wen-Xuan,Ru, Chao,et al. Placidenes G-J, Bioactive γ-Pyrone Derivatives From the Marine Mollusk Placida dendritica[J]. CHEMISTRY & BIODIVERSITY,2026,23(1):8. |
| APA | Wang, Hao,Li, Wen-Xuan,Ru, Chao,Gao, Zhen,&Li, Xu-Wen.(2026).Placidenes G-J, Bioactive γ-Pyrone Derivatives From the Marine Mollusk Placida dendritica.CHEMISTRY & BIODIVERSITY,23(1),8. |
| MLA | Wang, Hao,et al."Placidenes G-J, Bioactive γ-Pyrone Derivatives From the Marine Mollusk Placida dendritica".CHEMISTRY & BIODIVERSITY 23.1(2026):8. |
入库方式： OAI收割
来源：上海药物研究所
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