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Eremophilane-type sesquiterpenes from Ligularia hodgsonii: isolation , structural characterization, and pro-angiogenic potential

文献类型：期刊论文

作者Wan, Zhenhua1,7; Peng, Huilin5,6; Tang, Chunping1,4; Qin, Jiangjiang5; Hu, Bintao1; Ke, Changqiang1,4; Yao, Sheng1,3,7; Lin, Ligen2,6; Ye, Yang1,4,7
刊名PHYTOCHEMISTRY
出版日期2026-06-01
卷号246页码:12
关键词Ligularia hodgsonii Asteraceae Eremophilane-type sesquiterpene Hodgsonic acids A -J Hodgsonone A Pro-angiogenic activity
ISSN号0031-9422
DOI10.1016/j.phytochem.2026.114785
英文摘要A comprehensive chemical investigation of the rhizomes and roots of Ligularia hodgsonii Hook. was undertaken, which resulted in the identification of 11 previously undescribed eremophilane-type sesquiterpenes (1-4, 7-12, and 14), in addition to five known analogues (5-6, 13, and 15-16). The structures of previously undescribed compounds were fully characterized through comprehensive analysis of HRESIMS, 1D and 2D NMR spectroscopic data, single-crystal X-ray diffraction experiment, and time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculation. Compounds 1-12 represent six pairs of epimers at the C-11 position, and an empirical pattern to distinguish the C-11 stereochemistry was therefore established based on their characteristic Cotton effects in the ECD spectra, which was subsequently applied to revise the absolute configuration of the known compound 13. Furthermore, the pro-angiogenic activity of some isolated compounds was evaluated in human umbilical vein endothelial cells (HUVECs). Compound 14 exhibited potent effect by promoting HUVEC migration and facilitating the formation of capillary-like tubular networks, while compounds 7, 11, 13, and 15 interrupted wound healing in HUVECs. The findings provide the first insights into the bioactivity of eremophilane-type sesquiterpenes responsible for the wound-healing therapeutic effect of L. hodgsonii.
WOS关键词CONSTITUENTS ; LEAVES
资助项目National Key R&D Program of China[2022YFE0203600] ; International Governmental S&T Innovation Cooperation Project[2024YFE0117200] ; Ministry of Science and Technology of China ; Key Area Research and Development Program of Guangdong Province[2020B0303070002]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:001687056000001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/322963]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Yao, Sheng; Lin, Ligen; Ye, Yang
作者单位1.Shanghai Inst Mat Med, Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Univ Macau, Fac Hlth Sci, Dept Pharmaceut Sci, Macau 999078, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, China Serbia Belt & Rd Joint Lab Nat Prod & Drug D, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Hangzhou Inst Med, Hangzhou 310018, Zhejiang, Peoples R China
6.Univ Macau, Inst Chinese Med Sci, State Key Lab Mech & Qual Chinese Med, Macau 999078, Peoples R China
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wan, Zhenhua,Peng, Huilin,Tang, Chunping,et al. Eremophilane-type sesquiterpenes from Ligularia hodgsonii: isolation , structural characterization, and pro-angiogenic potential[J]. PHYTOCHEMISTRY,2026,246:12.
APA Wan, Zhenhua.,Peng, Huilin.,Tang, Chunping.,Qin, Jiangjiang.,Hu, Bintao.,...&Ye, Yang.(2026).Eremophilane-type sesquiterpenes from Ligularia hodgsonii: isolation , structural characterization, and pro-angiogenic potential.PHYTOCHEMISTRY,246,12.
MLA Wan, Zhenhua,et al."Eremophilane-type sesquiterpenes from Ligularia hodgsonii: isolation , structural characterization, and pro-angiogenic potential".PHYTOCHEMISTRY 246(2026):12.

入库方式： OAI收割

来源：上海药物研究所

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