Advances in fungal vaccine development: Progress in the face of emerging challenges
文献类型：期刊论文
| 作者 | Moses, Munika1; Huang, Xinhua1; Xue, Xinying2; Chen, Changbin1 |
| 刊名 | ISCIENCE
 |
| 出版日期 | 2025-12-19 |
| 卷号 | 28期号:12页码:17 |
| DOI | 10.1016/j.isci.2025.114091 |
| 通讯作者 | Xue, Xinying(xinyingxue2010@163.com) ; Chen, Changbin(cbchen@ips.ac.cn) |
| 英文摘要 | Historically overshadowed by bacterial and viral infections, fungal diseases are resurging globally, fueled by rising antifungal resistance and the increasing vulnerability of immunocompromised populations in healthcare settings. The widespread misuse and overuse of antifungals have accelerated the emergence of resistant fungal pathogens, complicating clinical management. Despite significant progress in vaccine development, with candidates such as NDV-3A and PEV7 advancing to late-stage trials, none have received FDA approval. Consequently, novel, more effective, and tolerable antifungal therapies are urgently needed. This review consolidates data on the progress made in fungal vaccine development, emphasizing key obstacles to clinical realization. It further proposes innovative strategies, such as bioinformatics-driven antigen discovery, nanotechnology-based delivery systems, reverse vaccinology, and the exploration of probioticvaccine synergies, which hold exceptional promise in overcoming these challenges and advancing the fight against fungal infections. |
| WOS关键词 | CANDIDA-ALBICANS ; ASPERGILLUS-FUMIGATUS ; IMMUNE-RESPONSE ; INFLUENZA VACCINATION ; STAPHYLOCOCCUS-AUREUS ; ANIMAL-MODELS ; T-CELLS ; IMMUNOGENICITY ; RECOMBINANT ; INFECTION |
| 资助项目 | National Key R&D Program of China[2022YFC2303500] ; National Natural Science Foundation of China[32170195] ; National Natural Science Foundation of China[32470200] ; Shanghai Science and Technology Innovation Action Plan 2023 Basic Research Project[23JC1404200] ; Shanghai Belt and Road Joint Laboratory Project[22490750200] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001633332700004 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/323002]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xue, Xinying; Chen, Changbin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Unit Pathogen Fungal Infect & Host Immun, Joint Lab Biomed Res & Pharmaceut Innovat, Shanghai 201203, Peoples R China 2.Capital Med Univ, Beijing Xuanwu Hosp, Dept Resp & Crit Care, Beijing 100038, Peoples R China |
| 推荐引用方式 GB/T 7714 | Moses, Munika,Huang, Xinhua,Xue, Xinying,et al. Advances in fungal vaccine development: Progress in the face of emerging challenges[J]. ISCIENCE,2025,28(12):17. |
| APA | Moses, Munika,Huang, Xinhua,Xue, Xinying,&Chen, Changbin.(2025).Advances in fungal vaccine development: Progress in the face of emerging challenges.ISCIENCE,28(12),17. |
| MLA | Moses, Munika,et al."Advances in fungal vaccine development: Progress in the face of emerging challenges".ISCIENCE 28.12(2025):17. |
入库方式： OAI收割
来源：上海药物研究所
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